After training, hepatic fat content was markedly reduced (P < 0.001), to a similar extent, in both the AER and the RES training groups (mean relative reduction from baseline [95% confidence interval] −32.8% [−58.20 to −7.52] versus −25.9% [−50.92 to −0.94], respectively). Additionally, hepatic steatosis (defined as learn more hepatic fat content >5.56%) disappeared in about one-quarter of the patients in each intervention

group (23.1% in the AER group and 23.5% in the RES group). Insulin sensitivity during euglycemic clamp was increased, whereas total body fat mass, VAT, SSAT, and hemoglobin A1c were reduced comparably in both intervention groups. Conclusion: This is the first randomized controlled study

to demonstrate that resistance training and aerobic training are equally effective in reducing hepatic fat content among type 2 diabetic patients with NAFLD. (Hepatology 2013;58:1287–1295) Type 2 diabetes is typically characterized Selleckchem PLX4032 by abdominal overweight/obesity and ectopic fat accumulation in several tissues and organs. In this regard, nonalcoholic fatty liver disease (NAFLD) is a very common pathologic condition in people with type 2 diabetes.[1] It has been estimated that ∼50%-70% of patients with type 2 diabetes have NAFLD, which is a spectrum of progressive liver disease encompassing simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. In the last decade, the role of NAFLD has raised considerable scientific interest, as liver fat infiltration plays an important role in the development of some metabolic disorders of diabetes (e.g., insulin resistance and atherogenic dyslipidemia) and is also linked to an increased risk of cardiovascular events.[1] To date, weight loss is the only recognized therapy for the treatment of NAFLD and lifestyle interventions are considered the cornerstone of management. Interestingly, exercise training has been shown to improve body fat distribution,

insulin sensitivity, glycemic control, and other 上海皓元医药股份有限公司 cardiometabolic risk factors in patients with type 2 diabetes.[2, 3] Although these beneficial exercise-induced changes could also favorably affect hepatic fat content in these patients, currently the evidence still remains elusive.[4, 5] Most cross-sectional studies carried out in nondiabetic subjects showed an association between physical activity and the prevalence of NAFLD,[4] suggesting that exercise is a useful tool to improve hepatic steatosis. However, data from intervention studies, which assessed the effects on hepatic fat of aerobic, resistance, or combined training, with or without diet, are scant and somewhat discordant.