This study aimed to clarify the effect of sodium restriction on prolonging the duration between the time when eGFR is 15 mL/min/1.73 m2 p38 MAP Kinase pathway to hemodialysis (HD) induction (G5 spans). Methods: Seventy-seven type 2 DKD patients (61 men and 16 women, mean age 58.6 ± 11.2 years) were recruited. All patients underwent frequent nutritional therapy and 24-h urine collection. Sodium intake was calculated using the 24-h urine collection. Patients

were divided into the following 2 groups: adequate group (AG: n = 39) defined as patients with sodium intake < 8.0 g/day, and over-intake group (OG: n = 32) defined as sodium intake ≧ 8.0 g/day. We retrospectively evaluated the G5 span between the 2 groups. Results: The Alisertib glycated hemoglobin value was 6.4 ± 1.8% when eGFR was firstly 15 mL/min/1.73 m2. In all patients, the G5 span was 556 ± 372 days, and the sodium intake was 7.9 ± 3.2 g/day. The G5 was significantly

longer in AG than in OG (660 ± 403 days vs. 487 ± 314 days, p < 0.05). Conclusion: Sodium restriction ameliorates the progression of renal dysfunction in type 2 advanced DKD patients (CKD stage G5). RAVI RAMA1,2, RAVI RAJALAKSHMI1,2, KURIEN ABRAHAM1,2, NAIR SANJEEV1,2, YUVARAJ ANAND1,2, ABRAHAM GEORGI1,2, RAVICHANDRAN SANGEETHA2, PANDIAN DEVI1,2 1Madras Medical Mission; 2Tamilnad Kidney Research Foundation Introduction: The current scenario of global burden of diseases comprise of a triple burden of diseases of which non communicable diseases form a huge proportion. Among the non communicable diseases, chronic kidney disease has emerged a major threat in terms of complications, accessibility and availability of treatment, especially in developing countries like India. There are a few studies done on prevalence of kidney disease and our programme targets early detection of kidney disease in the form of awareness and screening programmes directed at different segments of the society. Methods: The awareness programme

comprises of powerpoint presentation on basics of kidney functions and symptoms for early detection of kidney disease. The screening programme consists of brief history of medical illness, followed by measurement Janus kinase (JAK) of body mass index and blood pressure and urine examination to look for proteinuria. Results: We have so far conducted a total of 447 programmes of which 93.5% of the programmes were targeted to urban areas and we covered 79.2% of students through our awareness programmes. Our programme identified prehypertension in 38.7% of the population screened and 24.% were identified with proteinuria. Individuals who were above 45 years of age, and those with proteinuria were found to be significantly associated with abnormal serum creatinine and eGFR.