Methods: Maternal serum concentration of high-sensitivity CRP at 11-13 weeks’ gestation was measured in a case-control study of singleton pregnancies delivering phenotypically normal neonates, including 30 cases with spontaneous delivery before 34 weeks, with 15 cases presenting with contractions and 15 cases presenting with preterm premature rupture of membranes, and 90 matched
controls delivering after 37 weeks. The median multiple of the median (MoM) serum CRP in the two outcome groups was compared. Results: The median serum CRP MoM was not significantly different in the spontaneous early preterm delivery group compared to the term delivery group (1.101, IQR = 0.572-1.985 vs. 0.975, IQR
= 0.577-1.923; p = 0.813). The prevalence of CRP MoM above the 75th percentile was not significantly different between the early preterm delivery group compared to the click here term delivery group (26.7 vs. 24.4%; p = 0.811). In the preterm delivery group, the median serum CRP MoM in those presenting with contractions was not significantly different from those presenting with PPROM (1.175, IQR = 0.403-2.122 vs. 1.027, IQR = 0.659-1.940; p = 0.713). High-sensitivity CRP did not significantly improve prediction for preterm delivery over regular CRP. Conclusions: Measurement of maternal serum CRP at 11-13 weeks is unlikely to be useful in screening for spontaneous early preterm delivery.”
“In children primary tuberculosis disease is more common than reactivation disease. www.selleckchem.com/products/ch5424802.html Due to immunologic immaturity, the incidence of TB following ACY-1215 datasheet infection is higher in young children than in older children and adults. Children are immunologically, mature by about 5 years of age, at which time the incidence of TB falls to adult rates and they begin to get adult type disease. When you look at the IGRA studies in children with active TB, and put the studies
together, the numbers are still quite small. In seven reported studies looking at the sensitivity of the TST vs. QFT-G/GIT in active TB patients aged <18 years, the TST performs well in terms of sensitivity. The sensitivity of the IGRA in these combined studies is not as high, but the ranges in these seven studies are similar to what is seen in adults. There are less data for the T-SPOT.TB test, but in four available studies looking at children aged years, T-SPOT performs quite well. Regarding specificity in children with the IGRA, a German study of 28 children with confirmed TB reported good sensitivity and specificity data for both tests. (Specificity was low for the TST in this study.) The other study on IGRAs in children was a Korean study in BCG-vaccinated children where 62 children aged 2 months to 14 years of age were tested; none of them had a known risk for TB and none were QFT-positive.