The magnets, in the form of cylinders, were observed to decrepitate exclusively from the ends. High-resolution electron microscopy was QNZ nmr able to identify the presence of crack formation within the Nd(2)Fe(14)B grains, with the cracks running parallel to the c axis of these grains. Based on the concentration profile for hydrogen in a rare-earth transition-metal material, it is clear that the presence of hydrogen-induced cracks running perpendicular to the ends of the magnet provides
for a much more rapidly progressing hydrogen front in this direction than from the sides of the magnet. This results in the magnet exhibiting a macroscopic tendency to decrepitate from the poles of the magnet toward the center. This combination of microstructural modification via particle alignment as part of
the sintering process and direct observation via high-resolution electron microscopy has led to a satisfying explanation for the anisotropic hydrogen-decrepitation effect. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3348632]“
“DNA-based methods have emerged as an additional tool for Brucella infection-confirmation at a herd level. However, their JNK-IN-8 chemical structure implementation may require the use of specialized equipment. In this context the recently developed loop-mediated isothermal amplification (LAMP) technique may constitute an additional and cost-effective tool for rapid and specific DNA detection, especially in low income areas. In the present study the usefulness of a newly developed LAMP assay aiming at the multicopy-IS711 sequence was assessed on a variety of clinical samples (n = 81 from abortions and ewes; cattle, n = 3; swine, n = 4) that were analyzed in parallel using real-time PCR and bacteriology. Although check details overall sensitivities obtained with the three
methods were comparable (p > 0.05), our results highlighted the complementarity between bacteriology and molecular-based methods for increased sensitivity. Significant differences (p < 0.05) were observed with all techniques depending on the nature of the sample. Our results demonstrate the potential of the IS711-LAMP technique for direct Brucella detection. (c) 2013 Elsevier Ltd. All rights reserved.”
“BACKGROUND: Nebulized amphotericin B deoxycholate (n-ABD) is used to prevent Aspergillus infection in lung transplantation. Nebulized liposomal amphotericin B (n-LAB) is another option; however, no clinical data are available on the results of n-LAB for this purpose.
METHODS: In an observational study performed in 2 centers to assess the feasibility, tolerability, and outcomes of n-LAB prophylaxis, 104 consecutive patients undergoing prophylaxis with n-LAB were compared with 49 historical controls who received n-ABD. Patient follow-up lasted 12 months. The n-LAB prophylaxis regimen was 25 mg thrice weekly starting on the first post-operative day and continuing to 60 days, 25 mg once weekly from 60 to 180 days, and the same dose once every 2 weeks thereafter.