, 1984). This sort of process AZD6738 in vitro might increase the odds of the organism detecting any change in circumstances. Perhaps if there has been a history that adverse events

are controllable, it is reasonable in a new situation for the organism to continue attempts at active coping for a longer period of time than had the control experiences not occurred previously. The neural mechanisms proposed here would lead to this scenario. If, as argued here, the mPFC can exert inhibitory control over limbic and brainstem stress-responsive structures, and if there is plasticity in this circuitry initiated by control, then a number of clinical implications can be drawn. Strengthening of these pathways would lead to reduced passivity/withdrawal and the emotions that drive these behaviors, and weakening these pathways would have the opposite effect. If part of resistance/resilience is the maintenance of active coping in the face of adverse circumstances, then teaching individuals that they can influence what happens to them, how they feel, and how others see them, might alter how they respond to future adverse events in the direction of resistance/resilience. The writing of this paper was supported by MH050479. Numerous students and colleagues contributed enormously to the work reviewed. Special

thanks go to J. Amat, S. Bland, M. Baratta, J. Christianson, A. Der-Avakian, R. Drugan, R. Compound Library Grahn, J. Hammack, R. Jackson, K. Kubala, S. Maswood, T. Minor, K. Short, P. Sparks, L. Watkins, M. Will, and W. Woodmansee. “
“The stress response is characterized by a synchronized set of endocrine, immunological, autonomic, behavioral and cognitive responses to perceived threats that is necessary for survival and has been

conserved throughout evolution. The prevalence of stressors in the dynamic environment of an animal, make it essential to have mechanisms that limit activity of stress response systems and promote rapid recovery to pre-stress levels. For example, activation of the hypothalamic-pituitary-adrenal (HPA) axis by stress is under tight feedback regulation that serves to restrain Idoxuridine and terminate the response (Dallman et al., 1972). Dysfunctions in this feedback as a result of repeated or chronic stress or even a single severe stress are thought to underlie the link between stress and many neuropsychiatric diseases, including depression, post-traumatic stress disorder (PTSD), substance abuse and Alzheimer’s disease, as well as medical conditions including obesity, cardiovascular disease, inflammatory disorders and irritable bowel syndrome (Chrousos, 2000a, Chrousos and Gold, 1992, de Kloet et al., 2005, Goeders, 2003, McEwen, 1998, Larauche et al., 2012, Chrousos, 2000b and McEwen and Stellar, 1993).