Domain wall propagation has also been investigated in Co-based nearly zero magnetostrictive microwires, which become bistable under certain conditions. Wall velocity and mobility values were found to be superior in the latter type of microwires due to

their much smaller magnetoelastic anisotropy. In this paper, the key role played by the surface domain structure of microwires in determining the wall mobility is investigated. Wall velocity measurements have been performed on (Co(0.94)Fe(0.06))(72.5)Si(12.5)B(15) microwires in as-cast glass-coated state and after glass removal buy BYL719 with a hydrofluoric acid solution. Surface magnetization has been studied employing magneto-optical Kerr effect. The results show that both as-cast glass-coated microwires and microwires with the glass coating

removed, which are bistable, display a helical magnetization BIBF1120 in the surface region. The direction of the magnetization in this region affects the mobility of the propagating wall due to the stray fields associated with the preponderant components of the magnetization. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3068481]“
“The PedsQL (TM) (Pediatric Quality of Life Inventory (TM)) is a modular instrument designed to measure health-related quality of life and disease-specific symptoms. The PedsQL (TM) Cognitive Functioning Scale was developed as a brief generic symptom-specific instrument to measure cognitive functioning. The objective of the present study was to determine the feasibility, reliability, and validity of the PedsQL (TM) Cognitive Functioning Scale in pediatric liver transplant recipients.

The 6-item PedsQL (TM) Cognitive Functioning Scale and the PedsQL (TM) 4.0 Generic Core Scales were completed by pediatric liver transplant recipients ages 8-18 years (n = 215) and parents of pediatric liver transplant recipients ages 2-18 years (n = 502).

Both patient self-report and parent proxy-report were available for 212 cases. The 72-item Behavior Rating Inventory of Executive Function (BRIEF), a widely validated measure of executive functioning, was completed by 100 parents and 56 teachers on a subset of patients.

The PedsQL (TM) Cognitive Functioning Scale demonstrated MI-503 concentration minimal missing responses (0.0%, child report, 0.67%, parent report), achieved excellent reliability (alpha = 0.88 child report, 0.94 parent report), distinguished between pediatric patients with liver transplants and healthy children supporting discriminant validity, and was significantly correlated with the PedsQL (TM) 4.0 Generic Core Scales and the BRIEF supporting construct and concurrent validity, respectively. Pediatric liver transplants recipients experienced cognitive functioning comparable to long-term pediatric cancer survivors.

“
“We report on tailoring the magnetization reversal mechanism in engineered permalloy antidot nanostructures by lithographically introducing inhomogeneities in the form Ruboxistaurin mouse of neighboring

antidots with alternate dimensions. We observed that the magnetic domain configurations are significantly altered when compared to homogeneous antidots due to the dissimilar size of adjacent antidots. The reversal process also is strongly influenced by the relative difference in the size of adjacent antidots and the thickness of the permalloy film. Our results have been further corroborated by micromagnetic simulations and low temperature measurements. (C) 2011 American Institute of Physics. [doi:10.1063/1.3537948]“
“We present the neuropsychological and linguistic follow-up of a girl with bilateral perisylvian polymicrogyria during 4 years of gestural and verbal speech therapy. Some researchers have suggested that children with bilateral perisylvian polymicrogyria mentally fail to reach the syntactic phase and do not acquire a productive morphology. This patient achieved a mean length of utterance in signs/gestures of 3.4, a syntactic phase of completion of the nuclear sentence and the use of morphological modifications. We discuss

the link between gesture and language and formulate hypotheses on the role of gestural input on the reorganization of compensatory synaptic circuits.”
“Fe81-xCoxGa19 (with x ranging from 0 to 19 at.% Co) films with thicknesses of about 110 nm were deposited on Si(100) substrates by the dc magnetron sputtering method. The structures of these films at NSC23766 research buy room temperature (RT) were analyzed by x-ray diffraction. Magnetic

hysteresis loops of each film were measured from room temperature (RT) to 800 degrees C, and their saturation magnetization (4 pi M-S) and coercivity (H-C) were plotted as a function of temperature (T). Saturation magnetostriction (lambda(S)) at RT was also measured. The substitution of Co for Fe would give rise to increases in H-C and lambda(S). In terms of high temperature magnetic properties, SCH727965 (A) we find that for each film, there is one low-temperature-phase Curie point (T-C1) and one high-temperature-phase Curie point (T-C2); (B) based on the temperature dependence of 4 pi M-S, we calculated the reduced hyperbolic Bessel function (I) over cap (5/2)(T); from the relationship lambda(S)(T) = (I) over cap (5/2)(T) x lambda(S)(RT), we can compare the performances of lambda S(T) at higher temperatures; and (C) H-C decreases slightly as T increases initially, but it reaches a maximum when either T-C1 or T-C2 is approached. It is concluded that the Fe62Co19Ga19 film has the optimal high-temperature magnetic properties, including a larger lambda(S)(T), higher T-C1, and moderate H-C(T). (C) 2011 American Institute of Physics. [doi:10.1063/1.3560120]“
“Semantic dissociations show that biological stimuli present a further dissociation between animals and plant life.

“
“Study Design. Literature review of complications unrelated directly to surgical skills involved in

spinal deformity surgery.

Objective. Highlight complications associated with perioperative issues.

Summary of Background Data. Complications can arise from mundane events that arise during the operative experience, but are not directly related to surgical skills.

Methods. Literature reviews that touches on the more common potential complication events that do not involve direct surgical expertise.

Results. The topics of positioning, nutrition, blood loss, comorbidities, SCH 900776 cost OR time, and pulmonary and GI concerns are discussed as basics that could derail a surgical outcome even with an otherwise uneventful surgical technique. The need for vigilance is stressed and the nuances of understanding these are discussed.

Conclusion. Mundane events can derail a perfectly executed surgical undertaking. Attention to detail, team work, close monitoring, and checklist type focus will help to improve, focus, and avoid these preventable complications that

have nothing to do with direct surgical skills.”
“BACKGROUND: Heart transplant recipients are frequently exposed to ionizing radiation from various imaging and cardiac procedures. However, radiation exposure carries various risks, including GSK621 datasheet cancer. In this retrospective study, we calculated the mean cumulative radiation exposure during a 10-year period and the subsequent cancer risk after

heart transplantation.

METHODS: The study included all patients who underwent heart transplantation from August 1998 to July 2008 at our center. We identified all plain X-ray images, computed tomography, nuclear medicine procedures, and cardiac procedures (endomyocardial GS-9973 biopsies, right and left heart catheterization, and coronary angiograms) each patient underwent during the follow-up period. Radiation doses from cardiac procedures were the recorded exposures, and we used reference-values for plain X-ray imaging and nuclear medicine procedures.

RESULTS: The mean radiation dose was 84 mSv during the 10-year period, and cardiac procedures represented the largest radiation dose at 43.6 mSv (52%). The 10-year cumulative dose represented an additional 1 in 290 new cancers in the healthy population. Encouragingly, there was a decreasing trend of radiation exposure during the study period, with a mean decrease of 4.3 mSv per year.

CONCLUSION: Heart transplant patients are exposed to a 3.5 times greater dose of radiation per year compared with radiation from medical imaging in general population. The lifetime increase in cancer risk estimated from population studies was small. Although, there was a decreasing trend of radiation exposure during the study period, further reductions in radiation doses may be possible by the use of alternative imaging and non-imaging investigations.

This failure is partly due to the fact that many patients do not strictly adhere to their drug therapy and/or they report the presence of adverse effects. Traditionally, monotherapy is used as first-line treatment to achieve BP targets; however, when this fails, combination therapy is then required. In light of the need to attain BP goals, combination therapy (especially fixed-dose) is currently recommended. The main advantages of combination

therapy over monotherapy are not only that of reduced dose, improved GSK1210151A efficacy and reduced adverse effects, but also of target protection and reduced cardiovascular (CV) risk. Therefore, the development of single-administration drug combinations should also improve patient adherence to therapy and therefore help in achieving BP control. Among the various combinations available, calcium channel blockers (CCBs) and angiotensin-converting enzyme (ACE) inhibitors have been proven to be extremely effective, while also displaying good tolerability. Individually, both the third-generation CCB lercanidipine and the ACE inhibitor enalapril are effective antihypertensive p38 MAPK assay agents. In addition, both of these agents also show other beneficial effects when administered

as monotherapy. Of particular importance is the fact that when lercanidipine plus enalapril are administered in combination, they show synergism, thus providing added efficacy with reduced side effects. The present report provides an overview of the main clinical studies examining lercanidipine and enalapril administered as monotherapy, with particular focus on the potential renoprotective effects afforded by the fixed-dose combination lercanidipine-enalapril.”
“Objective-To determine whether dogs with p38 kinase assay renal failure have higher serum cardiac troponin I (cTnl) concentrations

than healthy dogs.

Design-Case-control study.

Animals-31 dogs with renal failure and 51 healthy dogs.

Procedures-Serum concentrations of creatinine and cardiac troponin 1, urine specific gravity, and systolic arterial blood pressure were measured for all dogs. Dogs underwent a standardized physical examination, and any dog with evidence of cardiovascular disease or other nonrenal disease was excluded from final analyses. Dogs were considered to be in renal failure when the serum creatinine concentration was >= 3.0 mg/dL, urine specific gravity was between 1.007 and 1.030, and renal failure had been clinically diagnosed.

Results-Dogs with renal failure had significantly higher serum cTnl concentrations (median, 0.35 ng/mL) than did healthy dogs (0.20 ng/mL). The renal failure group also had a significantly higher median systolic blood pressure (156 mm Hg) than did healthy dogs (138 mm Hg), although serum cTnl concentration was not correlated with systolic blood pressure in dogs with renal failure.

Copyright (C) 2010 John Wiley & Sons, Ltd.”
“K-m for L-phenylalanine, L-glutamic acid, L-aspartic acid, and the corresponding keto acids

were calculated, as well as V-max was measured for the following pairs of substrates: L-phenylalanine-2-ketoglutarate, L-phenylalanine-oxaloacetate, L-glutamic acid-phenylpyruvate, and L-aspartic acid-phenylpyruvate for aminotransferases PAT1, PAT2, and PAT3 from Erwinia carotovora catalyzing transamination of phenylpyruvate. The ping-pong bi-bi mechanism was shown for the studied aminotransferases. The substrate inhibition (K-s) of PAT3 with 2-ketoglutarate and oxaloacetate was 10.23 +/- 3.20 and 3.73 +/- 1.99 mM, respectively.

It VX-680 molecular weight was shown that L-beta-(N-benzylamino) alanine

was a competitive inhibitor with respect to L-phenylalanine for PAT1 (K-i = 0.32 +/- 0.07 mM, K-m = 0.45 +/- 0.1 mM, V-max = 11. 6 +/- 0.4 U/mg) at 25 mM concentration of 2-ketoglutarate in the reaction medium. L-beta-(N-methylamino) Selleckchem Proteasome inhibitor alanine is a noncompetitive inhibitor with respect to L-phenylalanine for PAT3 (K-I = 138.4 +/- 95.4 mM, Km = 13.7 +/- 3.9 mM, V-max = 18.6 +/- 4.1 U/mg) at 2 mM concentration of 2 – ketoglutarate in the reaction medium. L-stereo isomers of nonprotein analogues of aromatic amino acids were studied as substrates for PAT1, PAT2, and PAT3. L-beta-(2-Br-phenyl) alanine, L-beta-(4-Br-phenyl) alanine, L-beta-(2-F-phenyl) alanine, and L-(2-F) tryptophan were good substrates for all three aminotransferases; L-alpha-methyl-beta-(2-Br-phenyl) alanine and L-O-benzyltyrosine XMU-MP-1 cost were substrates only for PAT3; L-beta-(4-F-phenyl) alanine was a substrate for PAT1 and PAT3. Thus, these analogues of aromatic amino acids can be stereoselectively synthesized using the studied aminotransferases in the presence of the corresponding keto acids.”
“Objective: There is little information about the accuracy of patient perceptions of their life expectancy. Here, we compare patient perceptions of their outlook and their oncologist’s estimates of life expectancy to actual survival.

Methods:

The Unmet Needs Study recruited patients with metastatic cancer. Oncologists were asked to estimate patient survival as: (1) weeks; (2) months; (3) < 1 year; (4)< 2 years; and (5) > 2 years. Patients were asked to estimate their outlook on a numerical scale from 1-7. Patient and oncologist estimates were compared with actual survival.

Results: Complete survival data were available for 50 patients: median age 63.5 years; 48% male; tumor types: 32% colorectal, 24% lung, 10% upper gastrointestinal cancer, 12% unknown primary; and median survival 6.8 months. The oncologists were 32% accurate in predicting survival and overestimated survival 42% of the time (weighted kappa = 0.34).

Large grating period leads to higher-order coupled modes in the visible. This contributes to the “”family”" of the MPC fabrication techniques and lowers significantly the rigorous requirements on fabrication method of the large-area nanoscale MPCs. (c) 2011 American Institute of Physics. [doi: 10.1063/1.3647767]“
“The present study was aimed to investigate perinatal outcome of elderly nulliparous patients.

A retrospective study was performed

comparing pregnancy outcomes of nulliparous patients Selleckchem Lapatinib at three age groups: less than 35 years (reference group), 35-40 years, and above 40 years. The linear-by-linear association test was used to examine linear association between advanced maternal age and adverse pregnancy outcomes. A multiple logistic regression

model was used to control for confounders.

Out of 45,033 nulliparous women with singleton gestations, 1,036 were of women over the age of 35, and 188 over 40. A significant linear association was documented between advanced maternal age and adverse outcomes, such as intra uterine growth restriction, low birth weight, congenital malformations, and perinatal mortality. Using a multiple logistic Danusertib price regression model, controlling for gestational age, IUGR and malformations, advanced maternal age was not found to be an independent risk factor for perinatal mortality (adjusted odds ratio = 1.04, 95% confidence interval 0.7-1.4).

A significant linear association exists between advanced maternal age and adverse maternal and perinatal outcomes. Nevertheless, in our population, advanced maternal age is not an independent risk factor for perinatal mortality.”
“In this study, ethylenevinyl acetate (EVA) copolymer was melt-mixed with multiwalled carbon nanotube (MWCNT). To realize full-scale application of MWCNT to the polymer industries, the effect of melt-processing parameters on the surface resistivity in the polymer/MWCNT nanocomposites should be well-understood. The effect of mixing time, rotor speed, compression molding time, and temperature on the surface resistivity was investigated. Increasing the rotor

speed and longer mixing time lead to an improvement of dispersion of MWCNT in polymer matrix, resulting in a decrease of surface resistivity. The surface BMS-777607 mw resistivity of EVA/MWCNT nanocomposites is also sensitive to the press temperature and time. However, the dominant processing parameters to affect surface resistivity depend on the amount of MWCNT. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“We have investigated the growth mechanism and surface structure of magnetite (Fe3O4) films grown on semiconducting ZnO substrates. Growth proceeds in a wetting layer plus island-mode and a later coalescence of islands, as was verified by electron diffraction, topography measurements of the surface, and the investigation of the microstructure.

To compare VLDN to other types of donor nephrectomy, a prospective multicenter study must be performed.”
“We report that low frequency (up to 200 kHz) noise spectra of magnetic tunnel junctions with areas 10(-10) cm(2) at 10 K deviate significantly from

the typical 1/f behavior found in large area junctions at room temperature. In most cases, a Lorentzian-like shape with characteristic time between 0.1 and 10 ms is observed, which indicates only a small number of fluctuators contribute to the measured noise. By investigating the dependence of noise on both the magnitude and orientation of an applied magnetic field, we find that magnetization fluctuations in both free and reference layers are the main sources of noise in these devices. At small fields, where the noise from the free layer is dominant, a linear relation PHA-739358 mw between the measured noise and angular magnetoresistance Sapitinib mw susceptibility can be established. (C) 2011 American Institute of Physics. [doi:10.1063/1.3562039]“
“Hepatic

artery complications after living donor liver transplantation (LDLT) can directly affect both graft and recipient outcomes. For this reason, early diagnosis and treatment are essential. In the past, relaparotomy was generally employed to treat them. Following recent advances in interventional radiology, favorable outcomes have been reported with endovascular treatment. However, there is ongoing discussion regarding JQ-EZ-05 chemical structure the best and safe time for definitive endovascular

interventions. We herein report a retrospective analysis for six children with early hepatic artery complication after pediatric LDLT who underwent endovascular treatment as primary therapy at our institution. We evaluate the usefulness of endovascular treatment for hepatic artery complication and its optimal timing. The mean patient age was 11.9 months and mean body weight at LDLT was 6.7 kg. The mean duration between the transplantation and first endovascular treatment was 5.3 days. Five of the six patients were technically successful treated by only endovascular treatment. Of these five patients, two developed biliary complications. Endovascular procedures were performed 10 times in six patients without any complications and nine of the 10 procedures were successful. By selecting optimal devices, our findings suggest that endovascular treatment can be feasible and safe in the earliest time period after pediatric LDLT.”
“First-principles calculations were performed to investigate the pressure induced phase transition in SrRuO3 and to compare electronic structures and magnetism of A RuO3 (A = Ca, Sr, and Ba). By combining with the substitutions of Ca(Ba) for Sr in SrRuO3, ferromagnetism evolutions and its origin in A RuO3 are caused by the structural transition induced by the A(2+) ionic size.

The results

show that the CSP with poly[styrene-b-cellulose 2,3-bis(3,5-diphenylcarbamate)] could be used in THF and chloroform as eluents. The chiral resolutions of the commercial Chiracel OD, the CSP with cellulose 2,3-bis(3,5-dimethylphenylcarabmate), and the CSP with poly[styrene-b-cellulose 2,3-bis(3,5-dimethylphenylcarbamate)] prepared by SI-ATRP were examined. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122:3016-3022, 2011″
“PURPOSE: To compare 2 methods for optimizing the final central vault of a collagen copolymer posterior chamber phakic intraocular lens (pIOL) (Visian Implantable Col lamer Lens) in eyes with keratoconus and myopia.

SETTING: Private practice, Beverly Hills, California, USA.

DESIGN: Comparative FRAX597 price interventional study.

METHODS: The length of the pIOL to implant in keratoconic eyes with myopia was selected based on the white-to-white (WTW) distance or the sulcus-to-sulcus (STS) distance using the pIOL manufacturer’s protocol. The final central vault distance was compared a minimum of 3 months postoperatively.

RESULTS:

find more The pIOL length was based on WTW measurements in 8 eyes of 6 patients and on STS measurements in 8 eyes of 5 patients. There was no significant difference between the 2 groups in the mean preoperative WTW distance, STS distance, or manifest refraction spherical equivalent (MRSE) (P = .22, P = .37, and P = 1.00, respectively). The mean postoperative vault was 1.03 corneal thickness +/- 0.72 (SD) in the WTW group and 1.18 +/- 0.35 corneal thickness in the STS group (P = .61). The vault distance

was less than 1.0 corneal thickness SIS3 nmr in 3 eyes (37.5%) in the WTW group and 1 eye (12.5%) in the STS group. A small postoperative vault was associated with a high preoperative MRSE (P = .03).

CONCLUSIONS: The WTW and STS methods both provided adequate final central pIOL vault in keratoconic eyes with myopia. The STS calculations gave greater final vault and higher vault predictability, although the difference between the 2 methods was not statistically significant.”
“The analysis of cell-free fetal nucleic acids in maternal blood for prenatal diagnosis has been transformed by several recent profound technology developments. The most noteworthy of these are ‘digital PCR’ and ‘next-generation sequencing’ (NGS), which might finally deliver the long-sought goal of noninvasive detection of fetal aneuploidy. Recent data, however, indicate that NGS might even be able to offer a much more detailed appraisal of the fetal genome, including paternal and maternal inheritance of point mutations for mendelian disorders such as beta-thalassaemia. Although these developments are very exciting, in their current form they are still too complex and costly, and will need to be simplified considerably for their optimal translation to the clinic.

“
“We measured the reflectivity of nanoparticle thin films with bimodal size distributions clearly separated by depth and found distinctive spectral differences depending on the direction of illumination. In contrast with previous experiments that implied such differences, the samples in

this experiment are prepared by ion implantation at sufficiently high energy see more to achieve the necessary spatial separation between larger and smaller nanoparticles. We demonstrate that the difference between scattering and absorption probabilities as a function of nanoparticle size is responsible for the differences in maximum reflectivities as the direction of illumination is reversed. This conjecture is supported by a Mie scattering calculation.”
“Ge nanowires were grown on Au-coated Si (100) substrates using vapor-liquid-solid technique. Temperature dependent photoluminescence spectra of Mn doped nanowires showed dominant impurity emissions due to transition from an intermediate (4)T(1) to (6)A(1) ground state of Mn(2+) in Ge nanowire. Magnetic hysteresis loop showed paramagnetic

to ferromagnetic transition with decreasing temperature. Temperature dependent electrical resistivity indicated the formation of Mn related acceptor level in Ge at 0.159 eV from the valence band.”
“Objective. To examine the relationship between maternal glucose levels and intrauterine fetal adiposity distribution in GM6001 inhibitor women with a normal oral glucose tolerance test (OGTT) at 28 weeks gestation. Study Design. We recruited 231 women with a singleton pregnancy. At 28 and 37 weeks gestation, sonographic measurements of fetal body composition were performed. Multiple regression analysis was used to study the influence of different maternal variables on fetal adiposity distribution.

Results. Maternal glucose levels correlated with the fetal abdominal subcutaneous tissue measurements (r = 0.2; P = 0.014) and with birth weight (r = 0.1; QNZ in vivo P = 0.04). Maternal glucose levels did not correlate with the fetal mid-thigh muscle thickness and mid-thigh subcutaneous tissue measurements. Conclusion. We found that in nondiabetic women maternal glucose levels not only influence fetal adiposity and birth weight, but also influence the distribution of fetal adiposity. This supports previous evidence that maternal glycemia is a key determinant of intrauterine fetal programming.”
“Two-dimensional two-phase heterostructures have been the subject of many investigations including computer simulations. An outstanding issue is the shape analysis of the reflectance for dielectric inclusions of arbitrarily complex geometry.

The AGT gene promoter of each patient was sequenced to identify variants. AGT gene expression was studied by real-time PCR TaqMan assay. Clinical

data obtained before surgery were also considered in the statistical analysis. Two new polymorphisms at -175 and at -163 were identified. Although AGT expression was significantly higher in VAT than in the kidney, when both variants were present together AGT expression in VAT was about fivefold lower (P = 0.033) than in the wild haplotype. This lower AGT expression in VAT suggests that the proximity and linkage of -175A and -163A variants might destabilize the binding of specific transcription factors to an acute-phase responsive element 3. Among the known AGT promoter variants, only -20C SNP has an important effect on tissue-specific differential AGT expression XMU-MP-1 purchase in the human tissues studied, inducing a 3.8-fold increase in AGT mRNA localized only in the kidney medulla (P = 0.038). The other known polymorphisms (G-6A; G-217A) were not associated with different levels of AGT expression.

Our results support the hypothesis that some human AGT promoter MI-503 purchase variants influence transcriptional activity in a tissue-specific way in humans. Journal of Human Hypertension (2010) 24, 213-219; doi:10.1038/jhh.2009.48; published online 18 June 2009″
“In the present work, statistical (EOCs) and block (OBCs) ethylene-octene copolymers, with similar densities and crystallinities, were used as impact modifiers of isotactic polypropylene (iPP), and the toughening effects of these two types of elastomers were compared. The viscosity curves of EOCs were similar to those of OBCs with equivalent melt flow rate (MFR), enabling a comparison of the viscosity ratio and elastomer type as independent

variables. No distinct differences on the crystal forms and crystal perfection of iPP matrix this website in various blends were observed by thermal analysis. Morphological examination showed that OBCs form smaller dispersed domains than EOCs with similar MFRs. The flexural modulus, yield stress, stress and strain at break showed the same variation tendency for all the investigated polypropylene/elastomer blends. However, the room temperature Izod impact toughness of iPP/OBC blend was higher than that of iPP/EOC blend containing elastomer with the similar MFRs. The experimental results indicated that the compatibility of iPP/OBCs was much higher than that of iPP/EOCs. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 35913597, 2011″
“Epitaxial [gamma-Fe2O3-BiFeO3]/Bi3.25La0.75Ti3O12 and Bi3.25La0.75Ti3O12/[gamma-Fe2O3-BiFeO3] composite bilayers were grown on SrRuO3 coated (111) SrTiO3 substrates in order to investigate the influence of the morphology of the gamma-Fe2O3-BiFeO3 self assembled nanocomposite layer on the multiferroic properties of the bilayer. Both types of bilayers exhibit high resistivity and simultaneously ferroelectricity and ferrimagnetism at room temperature.