4 994 57.8 selleckchem Fatigue 3 0.3 10 0.6 Headache 1 0.1 3 0.2 Temperature > 38°C 3 0.3 9 0.5 Myalgia 33 2.9 119 6.9 Lymph node swelling 1 0.1 –   Mild local reaction 141 12.3 654 38.0 Strong local reaction 8 0.7 32 1.9 Total 1,144 100.0 1,720 100.0 * Multiple responses were possible Between 26 October 2009 and 2 March 2010, 245 HCWs with ILS (4.4%) were referred to the pH1N1 task force in the Emergency Department (Table 1). The peak in ILS and pH1N1 infection in HCWs came in the 49th week of 2009. ILS occurred less often in pH1N1-vaccinated HCWs (OR 0.7; 95% CI 0.51–0.95), while the seasonal TIV showed no protective effect against ILS (OR 1.0; 95% CI 0.79–1.36). Gender was not associated with ILS (Table 4). Younger workers were more likely to present with ILS (OR for ≤30 years: 2.7; 95% CI 1.69–4.42). After adjusting for vaccination, nurses (OR 2.5; 95% CI 1.53–4.09) and physicians (OR 2.0; 95% CI 1.21–3.41) had a higher risk of developing ILS than administrators.

Table 4 Logistic regression for putative risk factors of influenza-like symptoms (ILS) Variable ILS OR 95% CI Neg. Pos. N (%) N (%) pH1N1 vaccination  No 3,690 (95.3) 182 (4.7) 1 –  Yes 1,657 (96.3) 63 (3.7) 0.7 0.51–0.95 Seasonal TIV 09/10  No 2,658 (95.9) 115 (4.1) 1 –  Yes 2,689 (95.4) 130 (4.6) 1.0 0.79–1.36 Gender          Female 3,856 (95.4) 186 (4.6) 1 –  Male 1,491 Dibutyryl-cAMP research buy (96.2) 59 (3.8) 0.9 0.64–1.18 Age (years)  ≤30 1,379 (93.7) 92 (6.3) 2.7 1.69–4.42  31–40 1,638 (95.0) 86 (5.0) 2.3 1.42–3.72  41–50 1,191 (96.4) 45 (3.6) 1.8 1.01–3.03  >50 1,139 (98.1) 22 (1.9) 1 – Profession  Nurses 1,854 (93.5) 128 (6.5) 2.5 1.53–4.09  Physicians 1,330 (95.5) 63 (4.5) 2.0 1.21–3.41  Auxiliary staff 1,239 (97.3) 34 (2.7) 1.1 0.63–1.95  Administration or others 924 (97.9) 20 (2.1) 1 – Out of the 97 pH1N1 infections, 91 (94%) occurred in

non-vaccinated HCWs and two (2%) in 4-Aminobutyrate aminotransferase HCWs vaccinated less than a week before the onset of symptoms. Overall, pH1N1 incidence was 1.7% of all HCWs, affecting 0.3% of those vaccinated and 2.4% of those not vaccinated (Table 5). The seasonal TIV did not protect against pH1N1 infection (OR 1.5; 95% CI 0.98–2.27) and neither did consecutive seasonal TIV in 2008 and 2009 (Table 1) (data not shown). Young HCWs were more often affected (OR for ≤30 years: 6.6; 95% CI 2.57–16.8, Table 5). A total of 41 pH1N1 click here infections would have been expected in the vaccinated HCWs if they had not been vaccinated.