41 ± 0.77 1.47 ± 0.28 25 ± 6 38 ± 9 GP 111 ± 62 95 ± 49 1.03 ± 0.57 1.25 ± 0.23 26 ± 9 38 ± 11 COT 129 ± 71 121 ± 78 1.10 ± 0.88 1.27 ± 0.23 24 ± 5 35 ± 9 Values are expressed as mean ± SD; GC= creatine ABT-263 chemical structure supplemented athletes; GP= placebo (malthodextrin) AZD2014 datasheet supplemented athletes;

COT= non-supplemented control athletes. A significant 61% increase on the post-training mean value of uric acid was found for GC, when compared to GP and COT (7.4 ±1.6 mg/dL, 6.7 ± 2.3 mg/dL and 6.7 ± 1.2 mg/dL, respectively; p = 0.025), whereas no differences were seen for TBARS. Nevertheless, TAS values were significantly reduced for GC, in comparison to GP or COT (0.60 ± 0.19 mmol/L, 0.75 ± 0.22 mmol/L and 0.87 ± 0.42 mmol/L, respectively; p = 0.001). Furthermore, GC showed a significant 46% decrease Foretinib molecular weight for TAS, when comparing pre- and post-supplementation time (1.11 ± 0.34 mmol/L for pre- vs. 0.60 ± 0.19 mmol/L for post-supplementation time; p=0.025). Table 5 Effect of creatine supplementation and resistance training on oxidative stress markers Group Uric Acid (mg/dl) TBARS (ng/dl) TAS (mmol/l)   Pre Post Pre

Post Pre Post GC 4.6 ± 1.0 7.4 ± 1.6 a 216 ± 79 271 ± 92 1.11 ± 0.34 0.60 ± 0.19 b GP 4.4 ± 1.1 6.7 ± 2.3 209 ± 104 255 ± 77 0.91 ± 0.28 0.75 ± 0.22 COT 5.1 ± 0.9 6.7 ± 1.2 211 ± 96 264 ± 109 0.89 ± 0.15 0.87 ± 0.42 Values are expressed as mean ± SD; GC= creatine supplemented athletes; GP= placebo (malthodextrin) supplemented athletes; COT= non-supplemented control athletes; TBARS= Thiobarbituric Acid Reactive Substances; TAS= Total Antioxidant Status; a P value = 0.025 vs. Pre; b P value = 0.001 vs. Pre. Additionally, the differences between post- and pre-supplementation values were calculated and revealed that GC group displayed significant higher levels than GP and COT of uric acid (2.77 ±1.70 mg/dL, 2.26 ± 2.38 mg/dL and 1.00 ± 1.03 mg/dL, respectively; p = 0.0276) and strength (8.30 ± 2.26 kg, 5.29 ± 3.77 kg, and 5.29 ± 2.36 kg, respectively; p = 0,0209), and lower levels of TAS (−0.51 ± 0.36

Fludarabine nmr mmol/L, -0.11 ± 0.37 mmol/L and −0.02 ± 0.50 mmol/L, respectively; p = 0.0268). On the other hand, no differences were found for TBARS (Table 6). Table 6 Differences (post- vs. pre-training) on oxidative stress markers and strength Group Uric Acid (mg/dl) TBARS (ng/dl) TAS (mmol/l) Strength (kg) GC 2.77 ± 1.70 a 55 ± 98 −0.51 ± 0.36 b,c 8.30 ± 2,26 d,e GP 2.26 ± 2.38 40 ± 118 −0.11 ± 0.37 5.29 ± 3.77 COT 1.00 ± 1.03 48 ± 130 −0.02 ± 0.50 5.29 ± 2.36 Values are expressed as mean ± SD; GC= creatine supplemented athletes; GP= placebo (malthodextrin) supplemented athletes; COT= non-supplemented control athletes; TBARS= Thiobarbituric Acid Reactive Substances; TAS= Total Antioxidant Status; a P value = 0.0276 vs.