After adjustment for all potential confounding variables except maternal age, the HR for risk of BPAD for each 10-year increase in paternal age was 1.28 [95% confidence interval (Cl) 1.11-1.48], but this
fell to 1.20 (95% CI 0.97-1.48) after adjusting for maternal age. A similar result was found for maternal age and risk of BPAD [HR 1.30 (95% CI 1.08-1.56) before adjustment for paternal age, HR 1.12 PLX3397 mouse (95% Cl 0.86-1.45) after adjustment]. The HR associated with having either parent aged 30 years or over was 1.26 (95% CI 1.01-1.57) and it was 1.45 (95%, CI 1.16-1.81) if both parents were >30 years.
Conclusions. Unlike schizophrenia, the risk of BPAD seems to be associated with both paternal and maternal ages.”
“The time a phenotype takes to achieve a stationary state from an initial
condition depends on multiple factors. In particular, it AC220 is a function of both its fitness and its mutation rate. We evaluate the average time, referred to as the characteristic time, T-c, that the system takes to reach a final steady state of simple models of populations formed by self-replicative sequences. The dependence of T-c on the mutation rate and on the fitness landscape is also studied. For simple fitness landscapes, e.g. single peak, the characteristic time can be analytically obtained as a function of the system parameters. In this case, T-c for obtaining the quasispecies distribution presents a maximum at a Q-value that depends on the initial conditions and decreases monotonously as the mutation rate tends to zero. For most of the complex landscapes handled in this paper, the characteristic time to achieve the quasispecies distribution picked around the fittest phenotype attains a local minimum for a given mutation rate between 0 and the Q-value at which T-c reaches its local maximum. Thus, in these cases, an optimum value for the mutation rate exists that corresponds to the lowest value of the characteristic
time 4��8C for quasispecies evolution. (C) 2012 Elsevier Ltd. All rights reserved.”
“Background. Although central nervous system (CNS) involvement in adult myotonic dystrophy type I (DM1) was described long ago, the large number of variables affecting the cognitive and personality profile have made it difficult to determine the effect of DM1 on the brain. The aim of this study was to define the cognitive and personality patterns in adult DM1 patients, and to analyse the relationship between these clinical patterns and their association with the underlying molecular defect.
Method. We examined 121 adult DM1 patients with confirmed molecular CTG repeat expansion and 54 control subjects using comprehensive neuropsychological tests and personality assessments with the Millon Clinical Multiaxial Inventory (MCMI)-II. We used a multiple linear regression model to assess the effect of each variable on cognition and personality adjusted to the remainders.
Results.