Baseline total body weight was not significantly different (p = 0.326) between FEN and PL groups. There were no total body weight changes over the 8 week time course of the study between or within groups (p > 0.05). A significant main effect for time (p = 0.004) for lean body mass was observed, and further pair-wise comparisons revealed a significant increase in lean body mass for FEN at week 4 (p < 0.001) and week 8 (p < 0.001) compared with baseline. No such changes were seen in the PLA group (p > 0.005). A significant interaction effect (p < 0.001) and main effect for time (p < 0.001)

occurred between groups for body fat percentage. Additional pair-wise comparisons displayed significant improvements in body fat percentage at week

4 (p < 0.001) and week 8 (p < 0.001) in FEN compared to baseline, www.selleckchem.com/products/MLN-2238.html while no such changes were noticed in PLA (p > 0.005). Table 3 Body composition changes within and between groups Variable Group Baseline (T1) Week 4 (T2) Week 8 (T3) Between Group Body Weight FEN 90.2 ± 18.2 89.9 ± 18.2 90.4 ± 17.7 G = 0.305 (kg) PLA 85.7 ± 12.7 85.0 ± 13.9 85.8 ± 12.4 T = 0.244           G × T = 0.803 Lean Mass FEN 157.7 ± 23.9 160.2 ± 23.8‡ 162.6 ± 22.9‡ G = 0.640 (kg) PLA 157.2 ± 19.5 156.4 ± 22.4 158.2 ± 19.5 T = 0.004†           G × T = 0.057 Body Fat Obeticholic Acid chemical structure % FEN 19.4 ± 8.4 17.8 ± 8.4 ‡ 17.1 ± 8.6 ‡ G = 0.298   PLA 16.3 ± 4.8 16.0 ± 4.8 15.9 ± 4.5 T < 0.001†           G × T < 0.001† Abbreviations: FEN = fenugreek supplement group, PLA = placebo group Symbols: † = Significant between group difference (p < 0.05), ‡ = Within group difference from baseline (T1), p < 0.05 Training Adaptations Table 4 exhibits all training adaptation data. A significant group × time interaction (p = 0.008) and main effect Lepirudin for time (p < 0.001) was observed between FEN and PLA groups for bench press 1-RM, however pair-wise comparisons revealed no significant differences between FEN and PLA bench press 1-RM's at any time point.

Pair-wise comparisons also showed significant increases in bench press 1-RM at week 4 (p < 0.001) and week 8 (p < 0.001) in comparison with baseline and from week 4 to week 8 (p = 0.002) in FEN. PLA experienced significant increases in bench press 1-RM at week 4 (p = 0.008) and week 8 (p = 0.004) when compared to baseline. A significant group × time interaction (p < 0.001) and main effect for time (p < 0.001) was observed between FEN and PLA groups for leg press 1-RM, as further pair-wise comparisons indicated a significant difference in FEN compared to PLA at week 8 (p = 0.019). Pair-wise comparisons also revealed significant increases in leg press 1-RM at week 4 (FEN: p < 0.001, PLA: p < 0.001) and week 8 (FEN: p < 0.001, PLA: p < 0.001) in comparison with baseline. No significant interactions or main effects (p > 0.005) were noted for muscular endurance repetitions on the bench press or leg press. A significant main effect for time (p = 0.