Clinic and endoscopy manifestations should be combined in order to reaching early diagnosis. Key Word(s): 1. Allergic purpura;; 2. Endoscopy;; 3. Diagnosis; Presenting Author: YINCHANG AP24534 supplier QING Corresponding Author: YINCHANG QING Affiliations: The First Affiliated Hospital of Harbin Medical University Objective: To explore a small intestinal bacteria growth in the irritable bowel syndrome incidence in patients with IBS, to study whether symptoms ease is related to the control of SIBO, understand the relationship with IBS and SIBO. Methods: 72 patients with irritable bowel syndrome diagnosed by Rome III criteria and the control population
consisted of sex and age matched healthy subjects without irritable bowel syndrome symptoms (n = 42) are under investigation. All subjects underwent glucose hydrogen breath test to detect the basal value, Record symptoms and the incidence of SIBO-positive patients of all subjects. IBS patients with the existence of SIBO are given probiotics treatment for 2 weeks, after the treatment they are gonging to take the test again. Record the symptoms and the incidence check details of SIBO-positive. Clear whether the situation is improved by the change of symptom scores. Results: IBS group of 72 cases, 50 cases showed SIBO, the SIBO-positive rate was 69% vs the control group of 42 cases, 4 cases showed
SIBO, the SIBO-positive rate was 9.5%, the difference possess statistically significant (P < 0.05). The breath hydrogen concentration of most SIBO-positive patients decreased after the treatment, decrease of symptom scores were accompanied. The difference was proved with statistically significant (p < 0.05). Conclusion: The SIBO-positive rate in patients with IBS was higer than control groups. Symptoms of IBS patients are released after the treatment with bifidobacterium for 2 weeks, at the same time the why rate of SIBO-positive
decreased. Indicating the improvement of IBS patients was associated with the control of SIBO. There is a close relationship between IBS and SIBO. Key Word(s): 1. IBS; 2. HBT; 3. SIBO; Presenting Author: NA LIU Additional Authors: WEI QIAN, XIAOHUA HOU Corresponding Author: XIAOHUA HOU Affiliations: Union Hospital of Tongji Medical College, Huazhong University of Science and Technology; Union Hospital of Tongji Medical College, Huazhong University of Science and Technology Objective: NLRP6 inflammasome which is mainly in macrophages plays an important role in the regulation of intestinal excessive inflammation and environment stablization. The aim of this study is to investigate whether NLRP6 inflammasome participates in the activation of intestinal immune in post infectious irritable bowel syndrome (PI-IBS) models, and whether intragastric administration of Bifidobacterium longum has some effect on NLRP6 inflammasome.