e. exchange of oxygen and carbon dioxide.[25] Bellanger et al. [25] studied the interaction of alveolar epithelial cell lines with various antigenic sources including L. corymbifera by measuring the amount of IL-8
and IL-13, inflammatory and allergic cytokines, respectively. In their study, L. corymbifera was the only microorganism with increased up-regulation of IL-8 and IL-13 after 8 h of exposure in epithelial cells. This strongly indicates the possibility of L. corymbifera playing a crucial role in development of FLD. Generally fungi are considered as the most common microbes encountered by mammalian Tyrosine Kinase Inhibitor Library hosts. Fungi accounts for up to 4–11% of fine particle mass in urban and rural air.[26, 27] Fröhlich-Nowoisky et al. [27] stated that in their investigated air, nearly all detected fungal species were Basidiomycota (64%) or Ascomycota (34%), and with 2% from the Zygomycota. Mucorales are airborne and common inhabitant of soil. Therefore, it is agreeable that the route of entry to the host of the fungi is mainly via the respiratory tract. However, the infection does not occur as frequently despite of ubiquity of the fungal nature. Thanks to our efficient immunity, we have many different barriers
against the fungal invasion. Our immunity Dinaciclib supplier is comprised of two types; innate and adaptive. First one gives more rapid response compared to the later one. In this review, innate immune system will be scrutinised along with the cases of zygomycetes. The innate immune system allows immediate defence against foreign molecules such as pathogens. This system consists of various cellular components such as granulocytes, macrophages, mast cells, dendritic cells (DCs) and natural killer (NK) cells and soluble factors like complement proteins leading to clearance of pathogen, in this case, zygomycetes by phagocytic cells. The key players of the innate immune system participating in fungal invasion are illustrated in Fig. 3. According to many studies, innate immunity plays
a crucial role in mucormycosis by suppressing spore germination and/or hyphal growth. This statement is well met by high susceptibility 4-Aminobutyrate aminotransferase to mucormycosis among diabetic patients as they found to have altered or dysfunctional innate immunity.[7] A few studies were engaged in the comparison between zygomycetes with Aspergillus fumigatus, which is the most causative agent of mycoses. One of the reasons why cases of mucormycosis were less reported than those caused by A. fumigatus might be due to the size of the spores. Clearly, A. fumigatus spores are less in size than Mucorales and this by itself is likely to aid A. fumigatus spores to more easily deposited in the alveolar space when compared to the spores of the Mucorales, which are up to 6 times larger than A. fumigatus (average spore size 2–3 μm). Neutrophils are most abundant type of leucocytes in blood.