Electronic supplementary material Additional file 1: Figure S1. Title of data: Moderate steatosis db/db mice. Description of data: Hematoxylin and eosin staining showing mild to moderate steatosis in female and male db/db mice as compared to C57BKS mice livers. (PDF 20 MB) Additional file 2: Table S1. Title of data: Primary antibodies for western blot. Description of data: Type, dilution, molecular weight and sources of primary antibodies for western blot. (DOCX 16 KB) References
1. Wild S, Roglic G, Green A, Sicree R, learn more King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047–1053.PubMedCrossRef
2. Chiang DJ, Pritchard MT, Nagy LE: Obesity, diabetes mellitus, Rabusertib in vitro and liver fibrosis. Am J Physiol Gastrointest Liver Physiol 2011, 300:G697-G702.PubMedCrossRef 3. Lazo M, Clark JM: The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis 2008, 28:339–350.PubMedCrossRef 4. Lautamaki R, Borra R, Iozzo P, Komu M, Lehtimaki T, Salmi M, Jalkanen S, Airaksinen KE, Knuuti J, Parkkola R, Nuutila P: Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes. Am J Physiol Endocrinol Metab 2006, 291:E282-E290.PubMedCrossRef
5. Erickson SK: Nonalcoholic fatty Lck liver disease. J Lipid Res 2009,50(Suppl):S412-S416.PubMedCrossRef 6. Lu H, Sun J, Sun L, Shu X, Xu Y, Xie D: Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China. J Gastroenterol Hepatol 2009, 24:228–232.PubMedCrossRef 7. Friedman JM, Halaas JL: Leptin and the regulation of body weight in mammals. Nature 1998, 395:763–770.PubMedCrossRef 8. Farooqi IS, O’Rahilly S: Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009, 89:980S-984S.PubMedCrossRef 9. Rabe K, Lehrke M, Parhofer KG, Broedl UC: Adipokines and insulin resistance. Mol Med 2008, 14:741–751.PubMedCrossRef 10. Shifflet A, Wu GY: Non-alcoholic steatohepatitis: an overview. J Formos Med Assoc 2009, 108:4–12.PubMedCrossRef 11. Hummel KP, Dickie MM, Coleman DL: Diabetes, a new mutation in the mouse. Science 1966, 153:1127–1128.PubMedCrossRef 12. Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Kido Y, Hayashi Y, Nakayama KI, White MF, Kasuga M: Deletion of Cdkn1b ameliorates hyperglycemia by maintaining Liver X Receptor agonist compensatory hyperinsulinemia in diabetic mice. Nat Med 2005, 11:175–182.PubMedCrossRef 13.