Gut 2012, 61:43–52.PubMedCrossRef 18. Yan GR, Xu SH, Tan ZL, Yin XF, He QY: Proteomics characterization of gastrokine CX-5461 clinical trial 1-induced growth inhibition of gastric cancer cells. Proteomics 2011, 11:3657–3664.PubMedCrossRef 19. Toback FG, Walsh-Reitz MM, Musch MW, Chang
EB, Del Valle J, Ren H, Huang E, Martin TE: Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Am J Physiol Gastrointest Liver Physiol 2003, 285:G344-G353.PubMed 20. Moss SF, Lee JW, Sabo E, Rubin AK, Rommel J, Westley BR, May FE, Gao J, Meitner PA, Tavares R, Resnick MB: Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis. Clin Cancer Res 2008, 14:4161–4167.PubMedCrossRef 21. Vogler M: BCL2A1: the underdog in the BCL2 family. Cell Death Differ 2012, 19:67–74.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions Mao W and Chen J performed the experiments and wrote the paper;
Peng TL and Yin XF organized the figures and collected tissue specimens and patients’ data; Chen MH designed this study and supervised the writing and discussion. All authors GSK872 research buy have read and approved the final version of this manuscript.”
“Introduction Burkitt lymphoma is a high-grade, rapidly-growing and aggressive
B-cell non-Hodgkin’s lymphoma [1]. Three forms are recognized: http://www.selleck.co.jp/products/Neratinib(HKI-272).html those endemic to Africa, sporadic forms, and those associated with immunodeficiency states. In the endemic and sporadic forms, B lymphocytes possess rearranged immunoglobulin genes and most commonly carry the (8;14) chromosomal translocation of the proto-oncogene c-myc[1]. Although Burkitt lymphoma is sensitive to chemotherapy, the different regimens used to treat this cancer are associated with varied success rates [1, 2]. Prognosis depends on the stage of the disease at diagnosis and is generally worse for children, adolescents, and CB-839 solubility dmso patients with co-existent AIDS. Baicalin is one of several pharmacologically-active flavones present in Scutellaria baicalensis Georgi (Huang-qin or Chinese skullcap), a plant widely used in traditional Chinese herbal medicine [3]. Although baicalin is generally non-toxic to normal tissues, it exhibits strong anti-inflammatory, anti-viral, and anti-tumor activities [4, 5]. Growth of human leukemia and myeloma cells and of human hepatic, prostate, breast, lung, bladder, and estrogenic cancer cells is potently suppressed by this flavone. Molecular mechanisms underlying these growth-suppressive effects are thought to include changes in oxidation/reduction status, cell cycle inhibition, and induction of apoptosis [3–5].