In addition, it is recommended that the Hb level should not be maintained at 13 g/dL or higher. Furthermore, in ESA-resistant elderly patients with CKD, caution should be exercised against using high-dose ESA therapy. Instead, it is recommended that the cause of resistance to ESA should be MI-503 investigated. Bibliography 1. Singh AK, et al. N Engl J Med. 2006;355:2085–98. (Level 2)   2. Szczech LA, et al. Kidney Int. 2008;74:791–8. (Level 4)   3. Pfeffer MA, et al.

N Engl J Med. 2009;361:2019–32. (Level 2)   4. Solomon SD, et al. N Engl J Med. 2010;363:1146–55. (Level 4)   Is the target HbA1c of <6.9 % recommended for glycemic control in diabetic elderly patients with CKD? Elderly diabetic patients with CKD are at high risk of developing hypoglycemia and are often unaware of check details its signs. Therefore, glycemic control should be implemented with great care. There has been a limited number of studies investigating the target HbA1c in elderly diabetic patients with CKD. Tanaka et al. reported that an HbA1c level <8.2 % is the preferred target in these patients. After consideration of other guidelines, glycemic

control targeting an HbA1c level <8.2 % is recommended for elderly diabetic patients with CKD. Bibliography 1. Tanaka Y, et al. Diabetes Care. 1998;21:116–20. (Level 4)   2. Burge MR, et al. JAMA. 1998;279:137–43. (Level 2)   3. Ben-Ami H, et al. Arch Intern Med. MTMR9 1999;159:281–4. (Level 5)   4. Murata GH, et al. Diabetes Res Clin Pract. 2004;65:61–7. (Level 4)   Is statin therapy RG-7388 order recommended for preventing the progression of renal impairment in elderly CKD patients with dyslipidemia? There has only

been a limited number of studies assessing the efficacy of statins for preventing the progression of renal impairment, especially in elderly CKD patients with dyslipidemia. A meta-analysis conducted by Vidt et al. revealed short-term efficacy of rosuvastatin for improving renal function, but the long-term efficacy of statin remains to be explored. Therefore, statin therapy is recommended for elderly CKD patients with dyslipidemia since it may prevent the progression of renal impairment and can also reduce the risk of CVD events. A target lipid level of <120 mg/dL for LDL-C or <150 mg/dL for non-HDL-C is recommended for elderly patients with CKD as is the case for younger patients with CKD. Bibliography 1. Vidt DG, et al. Am J Cardiol. 2006;97:1602–6. (Level 1)   2. Barigent C, et al. Lancet. 2011;25:2181–92. (Level 2)   Is weight control recommended for obese elderly patients with CKD to slow the progression of CKD ? Obesity is recognized increasingly as a major risk factor for the progression of CKD.