IR spectroscopy and DSC studied the possible interaction between the drug and the carrier. The interaction often leads to identifiable changes in the IR profile and melting point of drug. The principal LEE011 solubility dmso IR peaks of pure zaltoprofen and IR peaks of Modulators spherical agglomerates were shown in Table 4, Fig. 2(a and b). No considerable changes were observed in the IR peaks of crystals when compared to pure zaltoprofen. These observations indicate

the absence of well-defined interaction between zaltoprofen, sodium CMC and other additives used in the crystals. The DSC thermograms of pure zaltoprofen and its crystal forms were shown in Fig. 3(a and b). Pure zaltoprofen showed a sharp endotherm at 140.81 °C corresponding to its melting point. Zaltoprofen spherical crystals showed sharp endotherm at 140.7 °C. There was

negligible change in the melting endotherms of the spherical crystals compared to pure drug. This observation further supports the IR spectroscopy results, which indicated the absence of any interactions between drug, sodium CMC and additives used in the preparation. However, there was a decrease, although very little, in the melting point of drug in spherical crystals compared to that of pure zaltoprofen. FTIR spectra and DSC studies of agglomerates showed that, the drug was stable in the prepared formulations indicating the absence of interactions between zaltoprofen and hydrophilic polymer and other excipients. Comparison of powder X-ray diffraction spectra of zaltoprofen and spherical agglomerates indicate considerable decrease in crystallinity of spherical agglomerates. Quizartinib concentration After the recrystallization, no polymorphic phenomenon was detected, as all powder X-ray diffraction patterns of primary crystals consisting of agglomerates were consistent with the pattern of original crystals. Crystallinity of the pure drug ranges between 0 and 4000 whereas spherical agglomerates falls

between 0 and 600. Calpain The decrease in crystallinity of the drug indicates increase in amorphous nature the drug, which may increase in the solubility of the drug. After the recrystallization, no polymorphic phenomenon is detected using X-ray diffractometer as all powder X-ray diffraction patterns of the primary crystals consisting of agglomerates were consistent with the pattern of original crystals Fig. 4(a and b). From the results of solubility and dissolution studies, the spherical agglomerates prepared from sodium CMC (2% w/v) showed maximum solubility and drug release in water compared to pure drug and other batches of spherical agglomerates. As Fig. 5 indicates F2 was dissolved 75.36% in 30 min where pure drug dissolved 60.6% in 30 min time. The results revealed that the spherical agglomerates with 2% w/v sodium CMC significantly increases the drug release compared to the pure drug.