\n\nIUGR was induced in pregnant rats by ligating the left vascular uterine pedicle at day 16 of gestation. BOLD MR imaging using a balanced steady-state free-precession (balanced-SSFP) sequence on a 1.5-T system was performed on day 19. Signal intensities (SI) before and after maternal hyperoxygenation were compared in the maternal liver and in control and PRIMA-1MET concentration growth-restricted foetoplacental units (FPUs).\n\nMaternal hyperoxygenation resulted in a significant increase in SI in all regions of interest (P < 0.05) in the 18 rats. In the control group, the SI (mean
+/- SD) increased by 21 % +/- 15 in placentas (n = 74) and 13 % +/- 8.5 in foetuses (n = 53). In the IUGR group, the increase was significantly lower: 6.5 % +/- 4 in placentas (n = 36) and 7 % +/- 5.5 in foetuses (n = 34) (P < 0.05).\n\nBOLD MRI allows non-invasive assessment of the foetoplacental response to maternal hyperoxygenation
in the rat and demonstrates its alteration in an IUGR model. This imaging method may provide a useful adjunct for the early diagnosis, evaluation, and management of human IUGR.\n\naEuro cent Intra-uterine growth restriction is an important cause of perinatal morbidity and mortality.\n\naEuro cent Blood oxygen level-dependent MRI non-invasively assesses foetoplacental response to maternal hyperoxygenation.\n\naEuro cent In the rat, foetoplacental response to maternal EPZ-6438 solubility dmso hyperoxygenation is altered in IUGR.\n\naEuro cent Functional MRI may help to assess human IUGR.”
“Caproate always appears during fermentative H(2) production but its formation was not well explained. It possibly results from the secondary
fermentation of ethanol and acetate or butyrate by some special species like Clostridium kluyveri. This study attempts to elucidate caproate formation during the fermentation H(2) production by using C. kluyveri as an example and evaluating several possible pathways of caproate formation. A detailed energetic analysis of the empirical data of an H(2)-producing reactor demonstrated that caproate can be formed from two substrates, either ethanol and acetate or ethanol and butyrate. The analysis showed that at least 5 mol ethanol per mole reaction was essential to support caproate formation under the experimental condition. The analysis also BI 2536 supplier indicated that the secondary fermentation by C. kluyveri might be another pathway to spontaneously produce H(2), butyrate, and acetate in addition to the butyrate-acetate pathway. Co-production of caproate and H(2) from ethanol was thermodynamically feasible and contributed to at least 10-20% of total H(2) production in the reactor studied. It is also clarified that caproate formation is hydrogenogenic rather than hydrogenotrophic. (C) 2010 Elsevier Ltd. All rights reserved.”
“Background: Hydrogen sulfide (H2S) has emerged as a third gaseous transmitter in mammals.