J Bone Miner Res 19:1259–1269PubMedCrossRef 52. Neele SJ, Evertz R, Valk-De Roo G, Roos JC, Netelenbos JC (2002) Effect of 1 year

of discontinuation of raloxifene or estrogen therapy on bone mineral density after 5 years of MLN8237 research buy treatment in healthy postmenopausal women. Bone 30:599–603PubMedCrossRef 53. Yood RA, Emani S, Reed JI, Lewis BE, Charpentier M, Lydick E (2003) Compliance with pharmacologic therapy for osteoporosis. Osteoporos Int 14:965–968PubMedCrossRef 54. Caro JJ, Ishak KJ, Huybrechts KF, Raggio G, Naujoks C (2004) The impact of compliance with osteoporosis therapy on fracture rates in actual practice. Osteoporos Int 15:1003–1008PubMedCrossRef 55. Huybrechts KF, Ishak KJ, Caro JJ (2006) Assessment of compliance with osteoporosis LY2874455 ic50 treatment and its consequences in a managed care population. Bone 38:922–928PubMedCrossRef 56. Siris ES, Harris ST, Rosen CJ et al (2006) Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc 81:1013–1022PubMedCrossRef 57. Olszynski WP, Adachi J, Davison J, Davison KS (2010) Disintegration times of brand and generic bisphosphonates available in Canada. J Bone Miner Res 25:S125 58. Epstein S, Cryer B, Ragi S et al (2003) Disintegration/dissolution YH25448 mw profiles of copies of Fosamax (alendronate). Curr Med Res Opin 19:781–789PubMedCrossRef 59. Dansereau

RJ, Crail DJ, Perkins AC (2008) In vitro disintegration and dissolution studies of once-weekly copies of alendronate sodium tablets (70 mg) and in vivo implications. Curr Med Res Opin 24:1137–1145PubMedCrossRef 60. Dansereau RJ, Crail DJ, Perkins AC (2009) In vitro disintegration studies of weekly generic alendronate sodium tablets (70 mg) available in the US. Curr Med Res Opin 25:449–452PubMedCrossRef 61. Almeida S, Almeida A, Filipe A et al (2006) In vitro disintegration and dissolution and in vivo bioequivalence of two alendronate once-weekly formulations. Arzneimittelforschung 56:84–89PubMed

62. Lamprecht G (2009) In vitro determination of the release of alendronic acid from alendronate tablets of different brands during deglutition. J Pharm Sci 98:3575–3581PubMedCrossRef Non-specific serine/threonine protein kinase 63. Perkins AC, Wilson CG, Frier M, Vincent RM, Blackshaw PE, Dansereau RJ, Juhlin KD, Bekker PJ, Spiller RC (1999) Esophageal transit of risedronate cellulose-coated tablet and gelatin capsule formulations. Int J Pharm 186:169–175PubMedCrossRef 64. Epstein S, Geusens P, Fisher JE et al (2005) Disintegration and esophageal irritation profiles of alendronate formulations: implications for clinical safety and efficacy. J Applied Res 5:253–264 65. Shakweh M, Bravo-Osuna I, Ponchel G (2007) Comparative in vitro study of oesophageal adhesiveness of different commercial formulations containing alendronate. Eur J Pharm Sci 31:262–270PubMedCrossRef 66. Department of Heath and Ageing (2011) Australian public assessment report for alendronic acid.