Nat Med 2007, 13:1510–1514.Selleckchem IWR 1 PubMedCrossRef 40. Wright JS 3rd, Jin R, Novick RP: Transient interference with staphylococcal quorum sensing blocks abscess formation. Proc Natl Acad Sci USA 2005, 102:1691–1696.PubMedCrossRef 41. Traber KE, Lee E, Benson S, Corrigan R, Cantera M, Shopsin B, Novick RP: agr function in clinical staphylococcus aureus isolates. Microbiology 2008, 154:2265–2274.PubMedCrossRef 42. Park SY, Chong
YP, Park HJ, Park KH, Moon SM, Jeong JY, Kim MN, Kim SH, Lee SO, Choi SH, Woo JH, Kim YS: agr dysfunction Milciclib price and persistent methicillin-resistant staphylococcus aureus bacteremia in patients with removed eradicable foci. Infection 2013, 41:111–119.PubMedCrossRef 43. Falkow S: Bacterial entry into eukaryotic cells. Cell 1991, 65:1099–1102.PubMedCrossRef 44. Garzoni C, François P, Huyghe A, Couzinet S, Tapparel C, Charbonnier Y, Renzoni A, Lucchini S, Lew DP, Vaudaux P, Kelley WL, Schrenzel J: A global view of staphylococcus aureus whole genome expression upon internalization in human epithelial cells. BMC Genomics 2007, 8:171.PubMedCrossRef 45. Wesson CA, Liou LE, Todd KM, Bohach GA, Trumble WR, Bayles KW: Staphylococcus aureus Agr and Sar global regulators https://www.selleckchem.com/products/pifithrin-alpha.html influence internalization and induction of
apoptosis. Infect Immun 1998, 66:5238–5243.PubMed 46. Pozzi C, Waters EM, Rudkin JK, Schaeffer CR, Lohan AJ, Tong P, Loftus BJ, Pier GB, Fey PD, Massey RC, O’Gara JP: Methicillin resistance alters the biofilm phenotype and attenuates virulence
in staphylococcus aureus device-associated infections. PLoS Pathog 2012, 8:e1002626.PubMedCrossRef 47. Rudkin JK, Edwards AM, Bowden MG, Brown EL, Pozzi C, Waters EM, Chan WC, Williams P, O’Gara JP, Massey RC: Methicillin resistance reduces the virulence of Dapagliflozin healthcare-associated methicillin-resistant staphylococcus aureus by interfering with the agr quorum sensing system. J Infect Dis 2012, 205:798–806.PubMedCrossRef 48. Morfeldt E, Tegmark K, Arvidson S: Transcriptional control of the agr -dependent virulence gene regulator, RNAIII, in staphylococcus aureus . Mol Microbiol 1996, 21:1227–1237.PubMedCrossRef 49. Beenken KE, Mrak LN, Griffin LM, Zielinska AK, Shaw LN, Rice KC, Horswill AR, Bayles KW, Smeltzer MS: Epistatic relationships between sarA and agr in staphylococcus aureus biofilm formation. PLoS One 2010, 5:e10790.PubMedCrossRef 50. CLSI: Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard. 9th edition. Wayne, PA: CLSI document M07-A9. Clinical and Laboratory Standards Institute; 2012. 51. De Jonge BLM, De Lencastre H, Tomasz A: Supression of autolysis and cell wall turnover in heterogeneous Tn 551 mutants of a methicillin-resistant staphylococcus aureus strain. J Bacteriology 1991, 173:1105–1110. 52.