Our results indicate that increased amygdala activation while viewing unpleasant pictures may preferentially facilitate immediate recognition memory in men relative to women. NeuroReport 21:273-276 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.”
“This Phase

I study of clofarabine with etoposide and cyclophosphamide for children with relapsed/refractory acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML) was conducted to determine the maximum tolerated dose (MTD), dose-limiting toxicities and the recommended phase 2 doses (RP2Ds). All three drugs were administered for five consecutive days ��-Nicotinamide research buy in induction and four consecutive days in consolidation, for a maximum of eight cycles. A total of 25 patients (20 ALL and 5 AML) were enrolled in five cohorts. An MTD was not reached. The RP2Ds of clofarabine, cyclophosphamide and etoposide were 40, 440 and 100 mg/m(2)/day, respectively. Complete remission (CR) was achieved in 10 patients (ALL: nine; AML: one), and CR without platelet recovery in six patients (ALL: two; AML: four) for an overall response rate of 64% (ALL: 55%; AML: 100%). Of the 16 responders, 9 patients proceeded to hematopoietic stem cell transplantation. In conclusion,

the combination of clofarabine, SHP099 etoposide and cyclophosphamide was well tolerated and effective in pediatric patients with relapsed/refractory leukemia. Of note, the phase II portion of the trial was amended after the occurrence of unexpected hepatotoxicity. see more The ongoing phase II study will evaluate the efficacy and safety of this regimen in ALL patients. Leukemia (2009) 23, 2259-2264; doi:10.1038/leu.2009.185; published online 10 September 2009″
“We investigated

the relationship between action-outcome contingency and stimulus-preceding negativity (SPN), a motivationally sensitive event-related potential. Neuroimaging studies have shown that insular cortex (a known source of the SPN) is more activated prior to rewards that are contingent on prior correct action than rewards that are given gratuitously. We compared two gambling tasks, one in which the participant attempted to guess the profitable key-press option (choice) and one in which rewards were simply given at random (no-choice). The SPN that developed in anticipation of feedback was larger in the choice condition, especially at right anterolateral sites. These findings suggest that the SPN specifically reflects the expectation of response reinforcement, rather than anticipatory attention toward emotionally salient stimuli. NeuroReport 21:277-281 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.”
“Acute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of myeloid blasts in the bone marrow. Here, we report the effects of the novel histone deacetylase inhibitor panobinostat (LBH589) in combination with doxorubicin on AML cells.