Science 1998, 282:1494–1497.CrossRefPubMed 5. Mulvey MA, Schilling JD, Hultgren

SJ: Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection. Infect Immun 2001, 69:4572–4579.CrossRefPubMed 6. Anderson GG, Palermo JJ, Schilling JD, Roth R, Heuser J, Hultgren SJ: Intracellular bacterial biofilm-like pods in urinary tract infections. Science 2003, 301:105–107.CrossRefPubMed 7. Johnson JR: Microbial virulence determinants and the pathogenesis of urinary tract infection. Selleckchem CT99021 Infect Dis Clin North Am 2003, 17:261–78. viii.CrossRefPubMed 8. Taylor PW: Bactericidal and bacteriolytic activity of serum against gram-negative bacteria. Microbiol Rev 1983, 47:46–83.PubMed 9. Martinez JJ, Mulvey MA, Schilling JD, Pinkner JS, Hultgren SJ: Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. EMBO J 2000,

19:2803–2812.CrossRefPubMed 10. Selvarangan R, Goluszko P, Popov V, Singhal J, Pham T, Lublin DM, Nowicki S, Nowicki B: Role of decay-accelerating factor domains and anchorage in internalization of Dr-fimbriated Escherichia coli. Infect Immun 2000, 68:1391–1399.CrossRefPubMed 11. Doye A, Mettouchi A, Bossis G, Clement R, Buisson-Touati C, Flatau G, Gagnoux L, Piechaczyk M, Boquet P, Lemichez E: CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion. Cell 2002, 111:553–564.CrossRefPubMed www.selleckchem.com/products/ABT-737.html 12. Springall T, Sheerin NS, Abe K, Holers VM, Wan H, Sacks SH: Epithelial secretion all of C3 promotes colonization of the upper urinary tract by Escherichia coli. Nat Med 2001, 7:801–806.CrossRefPubMed

13. Li K, Feito MJ, Sacks SH, Sheerin NS: CD46 (membrane cofactor protein) acts as a human epithelial cell receptor for internalization of opsonized uropathogenic Escherichia coli. J Immunol 2006, 177:2543–2551.PubMed 14. Li K, Sacks SH, Sheerin NS: The classical complement pathway plays a critical role in the opsonisation of uropathogenic Escherichia coli. Mol Immunol 2008, 45:954–962.CrossRefPubMed 15. O’Hanley P, Lark D, Falkow S, Schoolnik G: Molecular basis of Escherichia coli colonization of the upper urinary tract in BALB/c mice. Gal-Gal pili immunization prevents Escherichia coli pyelonephritis in the BALB/c mouse model of human pyelonephritis. J Clin Invest 1985, 75:347–360.CrossRefPubMed 16. Racusen LC, Monteil C, Sgrignoli A, Lucskay M, Marouillat S, Rhim JG, Morin JP: Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines. J Lab Clin Med 1997, 129:318–329.CrossRefPubMed 17. Caprioli A, Falbo V, Roda LG, Ruggeri FM, Zona C: Partial purification and characterization of an escherichia coli toxic factor that induces morphological cell alterations. Infect Immun 1983, 39:1300–1306.PubMed 18.