In the period between 2010 and January 1st, 2023, we scrutinized electronic databases such as Ovid MEDLINE, PubMed, Ovid EMBASE, and CINAHL. To evaluate the risk of bias in the relationships between frailty status and outcomes, and subsequently conduct meta-analyses, we utilized the Joanna Briggs Institute software. A narrative synthesis was utilized to examine how well age and frailty predict outcomes.
Twelve of the examined studies met the criteria for meta-analysis. The study revealed a correlation between frailty and hospital outcomes, including in-hospital mortality (OR=112, 95% CI 105-119), length of stay (OR=204, 95% CI 151-256), discharge to home (OR=0.58, 95% CI 0.53-0.63), and in-hospital complications (OR=117, 95% CI 110-124). In six studies employing multivariate regression analysis, frailty, rather than injury severity or age, proved a more consistent predictor of unfavorable outcomes and death in elderly trauma patients.
Hospitalized, frail older trauma patients are more susceptible to in-hospital mortality, prolonged length of stay, complications during their hospitalisation, and problematic discharge plans. For these patients, frailty is a more potent predictor of adverse outcomes compared to age. In terms of patient care, the classification of clinical standards, and the design of research trials, frailty status is expected to be a beneficial prognostic variable.
Frailty in older trauma patients is associated with a higher incidence of in-hospital death, longer hospitalizations, in-hospital complications, and undesirable discharge placements. read more For these patients, frailty's predictive power of adverse outcomes surpasses that of age. Patient management and research trial stratification likely benefit from frailty status as a valuable prognostic indicator.

In aged care facilities, polypharmacy, a practice with potential harm, is quite widespread amongst older residents. No double-blind, randomized, controlled trials on deprescribing multiple medications have been performed.
A three-arm, randomized controlled trial (open intervention, blinded intervention, and blinded control), enrolling individuals aged 65 and older (n=303; pre-specified recruitment target of n=954) residing in residential aged care facilities. The blinded treatment groups had medications slated for deprescribing encapsulated, while other medicines were either discontinued (blind intervention) or stayed active (blind control). The third open intervention arm saw the unblinding of deprescribing for targeted medications.
A female majority (76%) of the participants had an average age of 85.075 years. Deprescribing, in both intervention groups (blind -27 medicines, 95% CI -35 to -19; open -23 medicines, 95% CI -31 to -14), led to a substantial decrease in medication use over 12 months, compared to the control group's minimal decrease (0.3 medicines; 95% CI -10 to 0.4). This difference was statistically significant (P = 0.0053). The administration of 'as needed' medications did not noticeably rise as a result of tapering off routine prescriptions. No considerable distinctions in mortality were observed in the masked intervention arm (HR 0.93; 95% CI, 0.50–1.73; P = 0.83) or the open intervention group (HR 1.47; 95% CI, 0.83–2.61; P = 0.19) when contrasted with the control group.
During this investigation, a protocol-based deprescribing strategy successfully reduced medication burden by two to three prescriptions per individual. Pre-established recruitment targets were not achieved, thus making the effect of deprescribing on survival and other clinical endpoints uncertain.
Protocol-based deprescribing, as part of this study, showed efficacy in reducing the average number of medications per person by two to three. Criegee intermediate Because pre-specified recruitment targets were not reached, the impact of deprescribing on survival and other clinical outcomes remains unresolved.

The study aims to explore the current hypertension management in older people, in comparison to guidelines, and whether adherence varies depending on the overall health status of the individuals.
This research will establish the percentage of older persons who reach National Institute for Health and Care Excellence (NICE) blood pressure targets within one year of being diagnosed with hypertension and discover the determinants of achieving those targets.
Between June 1st, 2011, and June 1st, 2016, a nationwide study of Welsh primary care data, sourced from the Secure Anonymised Information Linkage databank, analyzed newly diagnosed hypertension cases among patients aged 65 years. The attainment of NICE guideline blood pressure targets, as evidenced by the most recent blood pressure reading within one year of diagnosis, constituted the primary outcome. A study was undertaken to identify predictors of target accomplishment through the application of logistic regression.
The study encompassed 26,392 participants (55% female, median age 71 years, interquartile range 68-77 years). Among this group, 13,939 (528%) achieved their target blood pressure within a median follow-up duration of 9 months. The likelihood of achieving target blood pressure increased among those with a history of atrial fibrillation (OR 126, 95% CI 111, 143), heart failure (OR 125, 95% CI 106, 149), and myocardial infarction (OR 120, 95% CI 110, 132), in comparison to individuals without these medical conditions, respectively. Upon adjusting for confounding variables, care home residence, the severity of frailty, and an increase in co-morbidity showed no association with the target's fulfillment.
In the elderly population with newly diagnosed hypertension, inadequate blood pressure control persists in nearly half of cases one year after diagnosis, with no apparent correlation between outcomes and factors like baseline frailty, multi-morbidity, or care home residency.
Blood pressure control proves insufficient in nearly half of elderly patients diagnosed with hypertension one year prior, with no demonstrable link to initial frailty, comorbidities, or residence in a care facility.

Earlier studies have revealed the key role of plant-based dietary options in promoting well-being. However, the presumed benefits of plant-based foods for dementia or depression are not uniformly applicable. A prospective investigation was undertaken to explore the link between a complete plant-based diet and the development of dementia or depression.
From the UK Biobank cohort, we selected 180,532 participants, who were without a history of cardiovascular disease, cancer, dementia, or depression at the baseline assessment. Based on 17 key food groups from Oxford WebQ, we calculated indices for overall plant-based diets (PDI), healthy plant-based diets (hPDI), and unhealthy plant-based diets (uPDI). bio-based inks Using UK Biobank's hospital inpatient data, the prevalence of dementia and depression was assessed. Cox proportional hazards regression models were employed to quantify the relationship between PDIs and the occurrence of dementia or depression.
A subsequent review of patient data documented 1428 cases of dementia and 6781 cases of depression during the follow-up phase. After accounting for various potential confounding factors and contrasting the highest and lowest quintiles across three plant-based dietary indices, the multivariable hazard ratios (95% confidence intervals) for dementia were 1.03 (0.87, 1.23) for PDI, 0.82 (0.68, 0.98) for hPDI, and 1.29 (1.08, 1.53) for uPDI. The hazard ratios (95% confidence interval) for depression associated with PDI, hPDI, and uPDI were: 1.06 (0.98-1.14) for PDI, 0.92 (0.85-0.99) for hPDI, and 1.15 (1.07-1.24) for uPDI.
A plant-based dietary pattern, bountiful in healthier plant foods, was correlated with a decreased chance of dementia and depression, in contrast to a plant-based diet that prioritizes less healthy plant foods, which was associated with a higher likelihood of developing dementia and depression.
A plant-based diet, emphasizing nutrient-dense plant-based foods, exhibited an association with a lower likelihood of dementia and depression; conversely, a plant-based diet prioritizing less-nutritious plant-based foods correlated with a greater risk of dementia and depression.
A potentially modifiable risk factor, namely midlife hearing loss, has links to dementia. Strategies in older adult services to combat both hearing loss and cognitive impairment may result in a decreased risk of dementia.
A study to understand current UK professional approaches to hearing evaluations within memory care settings, and cognitive assessments within hearing aid provision.
The national study examined through surveys. The online survey was distributed to NHS memory service professionals and audiologists in NHS and private adult audiology services via email and QR codes at conferences, during the timeframe between July 2021 and March 2022. The descriptive statistics are displayed below.
There were 135 professionals working in NHS memory services and 156 audiologists (68% NHS, 32% private sector) who responded to the survey. For workers in memory services, a substantial 79% estimate that more than 25% of their patients have considerable issues with hearing; 98% consider questions about hearing difficulties a crucial step, and 91% adhere to this practice; nonetheless, while 56% feel hearing tests in the clinic are helpful, a mere 4% actually conduct them. A considerable 36% of audiologists surmise that more than one quarter of their elderly patients experience substantial memory difficulties; 90% find cognitive evaluations valuable, but only 4% carry them out. The major impediments encountered consistently include inadequate training, a lack of time, and limited resources.
Professionals working in the fields of memory and audiology appreciated the advantages of tackling this comorbidity, yet inconsistencies remain in current service provision, thereby typically not addressing it.