The mean value of LV mass index was 90 ± 21 g/m2 in control group. It increased to 178 ± 29 g/m2 in hypertensive group (p < 0.001). EF% resulted of 61 ± 0.8% in controls (group I) and of 57 ± 0.9% in hypertrophic Dabrafenib chemical structure patients (group II). Differences

between two groups weren’t significant (NS) (Table 1). With reference to LAVI, a mean of 47 ± 5 mL/m2 was found in hypertensive-hypertrophic patients (group II). This value was significantly higher (p < 0.001) than that recorded in controls (group I) (23 ± 4 mL/m2). Normal values of TDE-MPI (0.34 ± 0.05) obtained in control-group Inhibitors,research,lifescience,medical significantly increased (p < 0.01) in patients with LV hypertrophy (0.46 ± 0.09). Particularly, IVCT resulted 28 ± 7 ms in healthy individuals, almost similar to that obtained in hypertensive patients (30 ± 8 ms), without significant differences (NS). On the contrary, IVRT was significantly (p < 0.001) prolonged (107 ± 9 ms) in Inhibitors,research,lifescience,medical hypertensives in comparison to healthy subjects (79 ± 6 ms). ET was

within the limits both in normals (315 ± 10 ms) and in hypertensive patients (312 ± 10 ms) (NS) (Table 3). Discussion LAV may be calculated by three different methods: the biplane area lengh; the biplane modified Simpson’s, and the prolate ellipse method.16) Significant differences among Inhibitors,research,lifescience,medical three diverse methods exist, even through all three shown highly satisfactory reproducibility. In this study, we used biplane Inhibitors,research,lifescience,medical Simpson’s method indexed for BSA, to obtain LAVI mesaured in mL/m2. Mean value of LAVI reported by several AA is 22 ± 6 mL/m2.17-21) In our healthy controls, a mean value of 23 ± 4 mL/m2 was found. This was reported as reference value for our laboratory. It is known that mechanical function of LA has described in three phases: reservoir; conduit, and contractile phase. The “reservoir” corresponds to the difference between maximal and minimum LA volumes occurring in the interval-just before the opening mitral valve and just before the aortic valve opening. “Conduit” is the early phase of ventricular diastole. The blood is passively transferred to left ventricle

just after mitral valve Inhibitors,research,lifescience,medical opening. “Contractile” phase or “booster pump” is calculated as the difference between minimum and pre-atrial contraction. It serves to augment the stroke volume. The contribution of three phases of LA function changes according to the diastolic properties of LV. In normal conditions, the contribution of reservoir, why conduit and contractile function of the LA to the LV filling is 40%, 35%, and 25% respectively. As LV relaxation worsens, the contribution of different LA phases gradually increases,22) in accordance with recent experiences performed in patients with LV diastolic dysfunction.23),24) In the present study, we evaluated the relationship between LAVI and LV diastolic dysfunction due to LV hypertrophy. LV diastolic impairment was demonstrated by the increase of IVRT and TDE-MPI.