These results show that although fatigued participants had severe (comorbid)
complaints, only in the case when symptoms persisted, altered GC sensitivity of immune cells was observed. (C) 2007 Elsevier Ltd. All rights reserved.”
“BACKGROUND: O-6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that counteracts chemotherapeutic cytotoxicity of alkylating agents such as temozolomide. Low levels of MGMT expression have been shown to correlate with longer survival in glioma patients treated with temozolomide. The same is true in pituitary adenomas.
OBJECTIVE: We investigated the immunohistochemical expression of MGMT in a variety of corticotroph adenoma subtypes to
determine CRM1 inhibitor the potential utility of temozolomide as a therapeutic agent.
METHODS: The tumors consisted of 40 cases this website of adrenocorticotropin-secreting pituitary tumors in Cushing disease, 12 Crooke cell adenomas, and 7 subtype I silent corticotroph adenomas. Staining for MGMT was assessed by light microscopy; nuclear reactivity was estimated semiquantitatively as present in < 10%, 10% to 25%, 25% to 50%, 50% to 75%, and > 75% of cells.
RESULTS: Immunoexpression showed no correlation with patient age, sex, tumor size, invasiveness, or recurrence in patients with Cushing disease. Among adrenocorticotropin- secreting adenomas associated with Cushing disease, most invasive (60%) and recurrent (86%)
tumors showed low MGMT immunopositivity, defined as < 25%. Most (75%) Crooke cell adenomas exhibited an MGMT immunoreactivity of <= 50%. All subtype I silent corticotroph adenomas showed < 10% MGMT staining.
CONCLUSION: Our descriptive findings of low MGMT expression in adrenocorticotropin- producing pituitary adenomas, particularly aggressive tumors, suggest that they may be suitable candidates for temozolomide therapy.”
“Ca2+ influx through plasma membrane wounds triggers a rapid-repair response that is essential for cell survival. Earlier studies showed that repair requires the exocytosis of intracellular vesicles. Exocytosis was thought to promote resealing by ‘patching’ the plasma membrane lesion or by facilitating bilayer restoration through reduction in Cyclin-dependent kinase 3 membrane tension. However, cells also rapidly repair lesions created by pore-forming proteins, a form of injury that cannot be resealed solely by exocytosis. Recent studies indicate that, in cells injured by pores or mechanical abrasions, exocytosis is followed by lesion removal through endocytosis. Describing the relationship between wound-induced exocytosis and endocytosis has implications for the understanding of muscular degenerative diseases that are associated with defects in plasma membrane repair.”
“Objectives. The current study examined emotional and cognitive reactions to daily stress.