This result is a significant contribution to the understanding of cell and substrate behavior during cell interaction with chemically active polymer in tissue engineering field. Due to plasma treatment and subsequent BSA grafting to polymer surface, the
cell adhesion and proliferation can be stimulated due to the presence of active functional groups on the surface, which improves the electrostatic interactions between substrates and cells. Acknowledgements This work was supported by the GACR under project P108/12/G108. References 1. Rebollar E, Frischauf I, Olbrich M, Peterbauer T, Hering S, Preiner J, Hinterdorferb P, Romaninb C, Heitz J: Proliferation of aligned mammalian cells on laser-nanostructured polystyrene. Anlotinib order Biomaterials 2008, 29:1796–1806.CrossRef 2. Puppi D, Chiellini F, Piras AM, Chiellini E: Polymeric materials for bone and cartilage repair. Prog Polym Sci 2010, 35:403–440.CrossRef 3. Leor J, Amsalem Y, Cohen S: Cells, scaffolds, and molecules for myocardial tissue engineering. Pharmacol Therapeut 2005, 105:151–163.CrossRef 4. Langer R, Tirrell DA: Designing materials for biology and medicine. Nature 2004, 428:487–492.CrossRef 5. Tabata Y: Biomaterial technology for tissue engineering applications. J R Soc Interface 2009,
6:311–324.CrossRef 6. Shen Q, Shi P, Gao M, Yu X, Liu Y, Luo L, Zhu Y: Progress on materials and scaffold fabrications applied to esophageal tissue engineering. Mater Sci Eng C 2013, 33:1860–1866.CrossRef 7. Nair LS, Laurencin check details CT: Polymers as biomaterials for tissue engineering and controlled drug delivery. Etofibrate Adv Biochem Eng Biot 2006, 102:47–90. 8. Oehr C: Plasma surface modification of polymers for biomedical use. Nucl Instrum Meth B 2003, 208:40–47.CrossRef 9. Gauvin R, Khademhosseini A, Guillemette M, Langer R: Emerging trends in tissue engineering. In Comprehensive Biotechnology. 2nd GSK2399872A research buy edition. Edited
by: Moo-Young M. Amsterdam: Elsevier B.V; 2011:251–263.CrossRef 10. McKellop H, Shen FW, Lu B, Campbell P, Salovey R: Development of an extremely wear-resistant ultra high molecular weight polyethylene for total hip replacements. J Orthop Res 1999, 17:157–167.CrossRef 11. Kang ET, Zhang Y: Surface modification of fluoropolymers via molecular design. Adv Mater 2000, 12:1481–1494.CrossRef 12. Lin YS, Wang SS, Chung TW, Wang YH, Chiou SH, Hsu JJ, Chou NK, Hsieh KH, Chu SH: Growth of endothelial cells on different concentrations of Gly-Arg-Gly-Asp photochemically grafted in polyethylene glycol modified polyurethane. Artif Organs 2001, 25:617–621.CrossRef 13. Švorčík V, Hnatowicz V, Stopka P, Bačáková L, Heitz J, Öchsner R, Ryssel H: Amino acids grafting of Ar + ions modified PE. Radiat Phys Chem 2001, 60:89–93.CrossRef 14. Rademacher A, Paulitschke M, Meyer R, Hetzer R: Endothelialization of PTFE vascular grafts under flow induces significant cell changes. Int J Artif Organs 2001, 24:235–242. 15.