Two subjects dropped out, as they found the procedure to be overly burdensome.

Data from the CIS and SF-36 questionnaires were available for all 25 subjects. The SHC yielded usable data from 24 subjects. Data on the HRV parameters (SDNN and RMSSD) for both conditions (reclining and cycling) were available for 24 subjects. For the cycling condition, RR data were available from 25 subjects; for the reclining condition, data were available from 23 subjects. Questionnaires Table 1 shows the number of subjects completing the questionnaires as well as the means and the Selleckchem Rabusertib VX 770 standard deviations of the total score on the CIS, the scores on four subscales of the MOS 36-item Short-Form Health Survey (SF-36) and the score on the subscale PN of the SHC questionnaire. Table 1 Number of subjects (N) completing the questionnaires and the means and standard deviations of the total score on the Checklist Individual Strength (CIS), the scores on four subscales

of the MOS 36-item Short-Form Health Survey (SF-36) and the score on the subscale Pseudoneurology (PN) of the Subjective Health Complaint SRT2104 supplier (SHC) questionnaire   CIS SF-36 SHC PF SF RLP RLEP PN N 25 25 25 25 25 24 Mean (standard deviation) 100.7 (22.5) 75.8 (14.6) 41.0 (21.2) 16.0 (23.8) 46.7 (43.0) 15.7 (9.7) PF physical functioning, SF social functioning, RLP role limitations due to physical problems, RLEP role limitations due to emotional problems The mean total score of all subjects on the CIS was 100.7. The scores on the four

SF-36 subscales ranged from 16.0 to 75.8. Finally, the mean score on the subscale PN of the SHC was 15.7. Parameters The number of subjects is presented in Table 2, along with the means and standard deviations of the HRV parameters SDNN, RMSSD and RR. Table 2 Number of measurements (N) used for analysis and the means and standard deviations for heart rate variability [SDNN (ms) and RMSSD (ms)] and respiration rate [RR (breaths/min)] required at measurement 1 (T1) and measurement 2 (T2)   Cycling Reclining N Mean (standard deviation) N Mean (standard deviation) SDNN (ms) nearly  T1 24 17.79 (8.89) 24 40.88 (19.77)  T2 24 19.08 (8.20) 24 42.75 (22.19) RMSSD (ms)  T1 24 6.67 (3.14) 24 15.33 (7.56)  T2 24 6.67 (2.68) 24 16.46 (8.67) RR (breaths/min)  T1 25 18.63 (5.11) 23 9.40 (3.07)  T2 25 17.94 (5.22) 23 9.67 (3.10) The mean SDNN was approximately 18 ms for the cycling condition and approximately 41 ms for the reclining condition. The mean values for RMSSD were approximately 7 ms for cycling and approximately 16 ms for reclining. The mean RR values were approximately 18 breaths/min while cycling and approximately 9 breaths/min while reclining. Reproducibility The number of measurements used for analysis, ICC, ICC 95% LoA and SEM values for both HRV parameters (SDNN and RMSSD) and for RR are presented in Table 3.