v.-irradiation or cisplatin. Oncogene 1996,13(10):2255–2263.PubMed 28. Tront JS, Huang Y, Fornace AJ Jr, Hoffman B, Liebermann DA: Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress. Cancer Res 2010,70(23):9671–9681.PubMedCrossRef 29. Zhang XY, Qu X, Wang CQ, Zhou CJ, Liu GX, Wei FC, Sun SZ: Over-expression of Gadd45a enhances radiotherapy efficacy

in human Tca8113 cell line. Acta Pharmacol Sin 2011,32(2):253–258.PubMedCrossRef Fludarabine purchase 30. Carrier F, Georgel PT, Pourquier P, Blake M, Kontny HU, Antinore MJ, Gariboldi M, Myers TG, Weinstein JN, Pommier Y, Fornace AJ Jr: PRIMA-1MET molecular weight Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol 1999,19(3):1673–1685.PubMed 31. Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB: DNA damage

activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell 2010,40(1):34–49.PubMedCrossRef 32. Zhan Q: Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage. Mutat Res 2005,569(1–2):133–143.PubMedCrossRef 33. Fornace AJ Jr, Jackman J, Hollander MC, Hoffman-Liebermann B, Liebermann DA: Genotoxic-stress-response genes and growth-arrest genes gadd, MyD, and other genes induced by treatments Wnt inhibitor eliciting growth arrest. Ann N Y Acad Sci 1992, 663:139–153.PubMedCrossRef 34. Fornace AJ Jr, Nebert DW, Hollander M, Luethy JD, Papathanasiou M, Fargnoli J, Holbrook NJ: Mammalian Etofibrate genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol 1989,9(10):4196–4203.PubMed 35. Ling ZQ, Li P, Ge MH, Hu FJ, Fang XH, Dong ZM, Mao WM: Aberrant Methylation of Different DNA Repair Genes Demonstrates Distinct Prognostic Value for Esophageal Cancer. Dig Dis Sci 2011,56(10):2992–3004.PubMedCrossRef 36. Tront JS, Hoffman B, Liebermann DA: Gadd45a suppresses Ras-driven mammary tumorigenesis

by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence. Cancer Res 2006,66(17):8448–8454.PubMedCrossRef 37. Pogribny IP, Beland FA: DNA hypomethylation in the origin and pathogenesis of human diseases. Cell Mol Life Sci 2009,66(14):2249–2261.PubMedCrossRef 38. Wilson AS, Power BE, Molloy PL: DNA hypomethylation and human diseases. Biochim Biophys Acta 2007,1775(1):138–162.PubMed 39. Hsiung DT, Marsit CJ, Houseman EA, Eddy K, Furniss CS, McClean MD, Kelsey KT: Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2007,16(1):108–114.PubMedCrossRef 40. Chen C, Yin N, Yin B, Lu Q: DNA methylation in thoracic neoplasms. Cancer Lett 2011,301(1):7–16.PubMedCrossRef 41.