Wild-type mice were used as controls. Macrophage targeting by Au-HDL was further evaluated by using transmission electron microscopy and confocal microscopy of aorta sections.
Results: Multicolor CT enabled differentiation of Au-HDL, iodine-based Fosbretabulin supplier contrast material, and calcium phosphate in the phantoms. Accumulations of Au-HDL were detected in the aortas of the apo E-KO mice, while the iodine-based
contrast agent and the calcium-rich tissue could also be detected and thus facilitated visualization of the vasculature and bones (skeleton), respectively, during a single scanning examination. Microscopy revealed Au-HDL to be primarily localized in the macrophages on the aorta sections; hence, the multicolor CT images provided information about the macrophage burden.
Conclusion: Spectral CT used with carefully chosen contrast agents may yield valuable information about atherosclerotic plaque composition.”
“CYP2D6 is part of the cytochrome P450 system, which catalyzes biotransformation of endogenous substrates and xenobiotics. Approximately 10% of the Caucasian population has two null alleles, resulting in a poor metabolizer (PM) status. Mostly, allele four (CYP2D6*4) is responsible for the PM status,
which is suspected to be associated with an accelerated fibrosis progression (FP). The aim of the present study was to analyze the role of the CYP2D6*4 genotype for FP after liver transplantation Compound C nmr (LT). Genotypes were determined in liver biopsies (donor) and peripheral blood (recipient) by fluorescence resonance energy transfer. Data were correlated with clinical variables and risk factors for fibrosis.
We analyzed 517 LTs performed between 1997 and 2009. Overall donor and recipient allele frequencies were comparable (18.0%, 20.5%; P = BMS-777607 datasheet 0.43). The donor genotype did not correlate with FP. In contrast, recipients carrying CYP2D6*4, showed a significant higher risk for an accelerated FP (P = 0.011) in HCV positive (P = 0.038) and HCV negative patients (P = 0.033). Results were confirmed by multivariate analysis (Hazard ratio 1.65; P = 0.001). The CYP2D6*4-associated PM status of the donor liver seems to have no influence on FP after LT. Recipients, carrying the allele, have an elevated risk for an accelerated FP.”
“This paper outlines a low-cost multimaterial, integrated passives approach involving suspension wicking of high-K dielectric and ferromagnetic nanoparticles into capillaries comprising inductor and capacitor passive devices. The suspension is deposited into a “”target well”" and nanoparticles are delivered to the passive via fluidic self-assembly, resulting in inductor and capacitor value improvements. The universality of this approach has been demonstrated through the fabrication and testing of both MEMS inductors and capacitors on a single substrate, which would otherwise be fabrication-intense using traditional fabrication methods.